Entity Details

Primary name VATE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36543
EntryNameVATE1_HUMAN
FullNameV-type proton ATPase subunit E 1
TaxID9606
Evidenceevidence at protein level
Length226
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesATP6V1E1

GO terms

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GOName
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005829 cytosol
GO:0005902 microvillus
GO:0008286 insulin receptor signaling pathway
GO:0008553 P-type proton-exporting transporter activity
GO:0016241 regulation of macroautophagy
GO:0016324 apical plasma membrane
GO:0016469 proton-transporting two-sector ATPase complex
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
GO:0033572 transferrin transport
GO:0034198 cellular response to amino acid starvation
GO:0034220 ion transmembrane transport
GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0051117 ATPase binding
GO:0070062 extracellular exosome
GO:0090383 phagosome acidification
GO:1902600 proton transmembrane transport

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR002842 V-type ATPase subunit EFamilyFamily
IPR038495 V-type ATPase subunit E, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617402 OMIMCutis laxa, autosomal recessive, 2C (ARCL2C)A form of cutis laxa, a disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, and a general connective tissue weakness. Most ARCL2C patients exhibit severe hypotonia as well as cardiovascular involvement. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01133 Tiludronic acidDrugbanksmall molecule