Entity Details
| Primary name |
GNAL_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | P38405 |
| EntryName | GNAL_HUMAN |
| FullName | Guanine nucleotide-binding protein G(olf) subunit alpha |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 381 |
| SequenceStatus | complete |
| DateCreated | 1994-10-01 |
| DateModified | 2021-06-02 |
GO terms
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| GO | Name |
| GO:0001664 | G protein-coupled receptor binding |
| GO:0003924 | GTPase activity |
| GO:0005525 | GTP binding |
| GO:0005834 | heterotrimeric G-protein complex |
| GO:0005886 | plasma membrane |
| GO:0007165 | signal transduction |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO:0007606 | sensory perception of chemical stimulus |
| GO:0031683 | G-protein beta/gamma-subunit complex binding |
| GO:0046872 | metal ion binding |
| GO:0070062 | extracellular exosome |
Subcellular Location
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Domains
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| Domain | Name | Category | Type |
| IPR000367 | G-protein alpha subunit, group S | Family | Family |
| IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit | Family | Family |
| IPR011025 | G protein alpha subunit, helical insertion | Family | Homologous superfamily |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 615073 | OMIM | Dystonia 25 (DYT25) | A form of dystonia, a disorder defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT25 is an autosomal dominant neurologic disorder characterized by adult onset of focal dystonia, usually involving the neck. The dystonia most often progresses to involve other regions, particularly the face and laryngeal muscles, and less commonly the trunk and limbs. The disease is caused by variants affecting the gene represented in this entry. |
Interactions
3 interactions