Entity Details

Primary name PBX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40424
EntryNamePBX1_HUMAN
FullNamePre-B-cell leukemia transcription factor 1
TaxID9606
Evidenceevidence at protein level
Length430
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesPBX1

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001654 eye development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001779 natural killer cell differentiation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006694 steroid biosynthetic process
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007420 brain development
GO:0007548 sex differentiation
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0030278 regulation of ossification
GO:0030325 adrenal gland development
GO:0030326 embryonic limb morphogenesis
GO:0035019 somatic stem cell population maintenance
GO:0035162 embryonic hemopoiesis
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048568 embryonic organ development
GO:0048666 neuron development
GO:0048706 embryonic skeletal system development
GO:0090575 RNA polymerase II transcription regulator complex
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR005542 PBXDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
617641 OMIMCongenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay (CAKUTHED)An autosomal dominant disorder characterized by variable congenital anomalies of the kidney and urinary tract, sometimes resulting in renal dysfunction or failure, dysmorphic facial features, and abnormalities of the outer ear. Most patients have hearing loss, and some may have global developmental delay. The disease is caused by variants affecting the gene represented in this entry.

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
PBX1_HUMANHXB1_HUMANBioGRID, HPRD, IntAct10052460 9482740 details
PBX1_HUMANPBX2_HUMANHPRD, MINT9482739 details
PBX1_HUMANMEIS2_HUMANBioGRID, IntAct, MINT11279116 20211142 20553494 26186194 28514442 32296183 details
PBX1_HUMANMEIS1_HUMANBioGRID, HPRD, IntAct10082572 10373562 10523646 20211142 20237320 20541704 details
PBX1_HUMANPKNX1_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10654609 19559479 20211142 25856340 26186194 26971355 28514442 9482740 details
PBX1_HUMANTLX1_HUMANUniProt19559479 details
PBX1_HUMANBRM1L_HUMANBioGRID, IntAct32296183 details
PBX1_HUMANEFHC1_HUMANBioGRID, IntAct32296183 details
PBX1_HUMANPIN1_HUMANBioGRID, IntAct32296183 details
PBX1_HUMANHXB5_HUMANBioGRID, IntAct32296183 details
PBX1_HUMANHXC8_HUMANBioGRID, IntAct16637071 32296183 details
PBX1_HUMANCDA7L_HUMANBioGRID, IntAct32296183 details
PBX1_HUMANHXC5_HUMANBioGRID, IntAct32296183 details
PBX1_HUMANF90A1_HUMANBioGRID, IntAct32296183 details
PBX1_HUMANPKNX2_HUMANIntAct20211142 details
PBX1_HUMANMYH10_HUMANBioGRID, HPRD12724421 details
PBX1_HUMANHXB7_HUMANBioGRID7729685 details
PBX1_HUMANHXA9_HUMANBioGRID, HPRD10082572 15161102 details
PBX1_HUMANHXD4_HUMANBioGRID, HPRD10523646 details
PBX1_HUMANHXD9_HUMANBioGRID10523646 details
PBX1_HUMANHXB8_HUMANBioGRID, HPRD11571641 details
PBX1_HUMANHXA10_HUMANBioGRID, HPRD12145285 14512427 details
PBX1_HUMANPO2F1_HUMANBioGRID15138251 details
PBX1_HUMANCBP_HUMANBioGRID11585930 details
PBX1_HUMANPDX1_HUMANBioGRID11279116 details
PBX1_HUMANNED4L_HUMANBioGRID19664597 details
PBX1_HUMANKAT2A_HUMANBioGRID23044487 details
PBX1_HUMANMDM2_HUMANBioGRID23044487 details
PBX1_HUMANSMRD3_HUMANBioGRID, HPRD14701856 details
PBX1_HUMANFOXC1_HUMANBioGRID, MINT, UniProt15684392 25609649 details
PBX1_HUMANGCR_HUMANBioGRID, HPRD12487626 details
PBX1_HUMANMYOD1_HUMANBioGRID20195544 details
PBX1_HUMANSMCA4_HUMANBioGRID15870273 details
PBX1_HUMANHDAC1_HUMANBioGRID11046157 details
PBX1_HUMANHDAC3_HUMANBioGRID11046157 details
PBX1_HUMANSIN3B_HUMANBioGRID11046157 details
PBX1_HUMANESR1_HUMANBioGRID28336670 details
PBX1_HUMANUSP9X_HUMANBioGRID30718275 details
PBX1_HUMANMN1_HUMANBioGRID31839203 details
PBX1_HUMANPAX6_HUMANHPRD11069920 details
PBX1_HUMANHXA5_HUMANHPRD8657138 details
PBX1_HUMANHXD10_HUMANHPRD10523646 details