Entity Details

Primary name S26A3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40879
EntryNameS26A3_HUMAN
FullNameChloride anion exchanger
TaxID9606
Evidenceevidence at protein level
Length764
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesSLC26A3

GO terms

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GOName
GO:0005215 transporter activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006820 anion transport
GO:0007588 excretion
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019531 oxalate transmembrane transporter activity
GO:0031526 brush border membrane
GO:0048240 sperm capacitation
GO:0051454 intracellular pH elevation
GO:0060081 membrane hyperpolarization
GO:0071320 cellular response to cAMP
GO:0097225 sperm midpiece

Subcellular Location

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Subcellular Location
Apical cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR001902 SLC26A/SulP transporterFamilyFamily
IPR002645 STAS domainDomainDomain
IPR011547 SLC26A/SulP transporter domainDomainDomain
IPR018045 Sulphate anion transporter, conserved siteSiteConserved site
IPR030321 Solute carrier family 26 member 3 (DRA)FamilyFamily
IPR036513 STAS domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
214700 OMIMDiarrhea 1, secretory chloride, congenital (DIAR1)A disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
S26A3_HUMANNHRF2_HUMANBioGRID, MINT12369822 details
S26A3_HUMANNHRF1_HUMANHPRD12369822 details