Entity Details

Primary name WNT5A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41221
EntryNameWNT5A_HUMAN
FullNameProtein Wnt-5a
TaxID9606
Evidenceevidence at protein level
Length380
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesWNT5A

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001736 establishment of planar polarity
GO:0001756 somitogenesis
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001947 heart looping
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0003138 primary heart field specification
GO:0003139 secondary heart field specification
GO:0003283 atrial septum development
GO:0003323 type B pancreatic cell development
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0003408 optic cup formation involved in camera-type eye development
GO:0005109 frizzled binding
GO:0005115 receptor tyrosine kinase-like orphan receptor binding
GO:0005125 cytokine activity
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007257 obsolete activation of JUN kinase activity
GO:0007411 axon guidance
GO:0007442 hindgut morphogenesis
GO:0007494 midgut development
GO:0008584 male gonad development
GO:0008595 anterior/posterior axis specification, embryo
GO:0009986 cell surface
GO:0010033 response to organic substance
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010820 positive regulation of T cell chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0019904 protein domain specific binding
GO:0021891 olfactory bulb interneuron development
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030324 lung development
GO:0030514 negative regulation of BMP signaling pathway
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031012 extracellular matrix
GO:0031343 positive regulation of cell killing
GO:0032092 positive regulation of protein binding
GO:0032148 activation of protein kinase B activity
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0035567 non-canonical Wnt signaling pathway
GO:0036342 post-anal tail morphogenesis
GO:0036517 chemoattraction of serotonergic neuron axon
GO:0036518 chemorepulsion of dopaminergic neuron axon
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042733 embryonic digit morphogenesis
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045165 cell fate commitment
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045766 positive regulation of angiogenesis
GO:0045778 positive regulation of ossification
GO:0045807 positive regulation of endocytosis
GO:0045836 positive regulation of meiotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0048018 receptor ligand activity
GO:0048022 negative regulation of melanin biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048341 paraxial mesoderm formation
GO:0048570 notochord morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048806 genitalia development
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048850 hypophysis morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050807 regulation of synapse organization
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051216 cartilage development
GO:0051885 positive regulation of timing of anagen
GO:0051964 negative regulation of synapse assembly
GO:0060028 convergent extension involved in axis elongation
GO:0060029 convergent extension involved in organogenesis
GO:0060065 uterus development
GO:0060067 cervix development
GO:0060068 vagina development
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060157 urinary bladder development
GO:0060324 face development
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060744 mammary gland branching involved in thelarche
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0060760 positive regulation of response to cytokine stimulus
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation
GO:0060809 mesodermal to mesenchymal transition involved in gastrulation
GO:0060907 positive regulation of macrophage cytokine production
GO:0061024 membrane organization
GO:0061036 positive regulation of cartilage development
GO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354 planar cell polarity pathway involved in pericardium morphogenesis
GO:0062009 secondary palate development
GO:0070062 extracellular exosome
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071277 cellular response to calcium ion
GO:0071300 cellular response to retinoic acid
GO:0071346 cellular response to interferon-gamma
GO:0071425 hematopoietic stem cell proliferation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0090009 primitive streak formation
GO:0090037 positive regulation of protein kinase C signaling
GO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090630 activation of GTPase activity
GO:0097325 melanocyte proliferation
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099054 presynapse assembly
GO:0099068 postsynapse assembly
GO:0099175 regulation of postsynapse organization
GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration
GO:0150012 positive regulation of neuron projection arborization
GO:1900020 positive regulation of protein kinase C activity
GO:1901216 positive regulation of neuron death
GO:1902379 chemoattractant activity involved in axon guidance
GO:1902474 positive regulation of protein localization to synapse
GO:1903827 regulation of cellular protein localization
GO:1904861 excitatory synapse assembly
GO:1904862 inhibitory synapse assembly
GO:1904934 negative regulation of cell proliferation in midbrain
GO:1904938 planar cell polarity pathway involved in axon guidance
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1904955 planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000052 positive regulation of non-canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR005817 WntFamilyFamily
IPR018161 Wnt protein, conserved siteSiteConserved site
IPR026538 Wnt-5a proteinFamilyFamily
IPR043158 Wnt, C-terminal domainFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
180700 OMIMRobinow syndrome, autosomal dominant 1 (DRS1)A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. The disease is caused by variants affecting the gene represented in this entry.