Entity Details

Primary name KDM5C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41229
EntryNameKDM5C_HUMAN
FullNameLysine-specific demethylase 5C
TaxID9606
Evidenceevidence at protein level
Length1560
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesKDM5C

GO terms

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GOName
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006338 chromatin remodeling
GO:0008270 zinc ion binding
GO:0009636 response to toxic substance
GO:0032452 histone demethylase activity
GO:0032453 histone demethylase activity (H3-K4 specific)
GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)
GO:0034720 histone H3-K4 demethylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048511 rhythmic process
GO:0051213 dioxygenase activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001606 ARID DNA-binding domainDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003347 JmjC domainDomainDomain
IPR003349 JmjN domainDomainDomain
IPR004198 Zinc finger, C5HC2-typeDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013637 Lysine-specific demethylase-like domainDomainDomain
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR036431 ARID DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300534 OMIMMental retardation, X-linked, syndromic, Claes-Jensen type (MRXSCJ)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSCJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism. The disease is caused by variants affecting the gene represented in this entry.