Entity Details

Primary name SYIC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41252
EntryNameSYIC_HUMAN
FullNameIsoleucine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length1262
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesIARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0001649 osteoblast differentiation
GO:0002161 aminoacyl-tRNA editing activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0051020 GTPase binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR002300 Aminoacyl-tRNA synthetase, class IaDomainDomain
IPR002301 Isoleucine-tRNA ligaseFamilyFamily
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domainFamilyHomologous superfamily
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-bindingDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR023586 Isoleucine-tRNA ligase, type 2FamilyFamily
IPR033709 Isoleucyl tRNA synthetase type 2, anticodon-binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
617093 OMIMGrowth retardation, impaired intellectual development, hypotonia, and hepatopathy (GRIDHH)An autosomal recessive disorder characterized by severe growth retardation with prenatal onset, intellectual disability, muscular hypotonia, and hepatic dysfunction. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00167 IsoleucineDrugbanksmall molecule