Entity Details

Primary name PK3CA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42336
EntryNamePK3CA_HUMAN
FullNamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
TaxID9606
Evidenceevidence at protein level
Length1068
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPIK3CA

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001889 liver development
GO:0001944 vasculature development
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0005944 phosphatidylinositol 3-kinase complex, class IB
GO:0006006 glucose metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0010468 regulation of gene expression
GO:0010592 positive regulation of lamellipodium assembly
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030295 protein kinase activator activity
GO:0030835 negative regulation of actin filament depolymerization
GO:0031295 T cell costimulation
GO:0032008 positive regulation of TOR signaling
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035994 response to muscle stretch
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0043276 anoikis
GO:0043457 regulation of cellular respiration
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0043542 endothelial cell migration
GO:0043560 insulin receptor substrate binding
GO:0044029 hypomethylation of CpG island
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0052742 phosphatidylinositol kinase activity
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:0055119 relaxation of cardiac muscle
GO:0060048 cardiac muscle contraction
GO:0060612 adipose tissue development
GO:0071333 cellular response to glucose stimulus
GO:0071464 cellular response to hydrostatic pressure
GO:0086003 cardiac muscle cell contraction
GO:0097009 energy homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110053 regulation of actin filament organization
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000653 regulation of genetic imprinting
GO:2000811 negative regulation of anoikis

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainDomainDomain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domainDomainDomain
IPR002420 C2 phosphatidylinositol 3-kinase-type domainDomainDomain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015433 Phosphatidylinositol kinaseFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR037704 PI3Kalpha, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB05241 XL765Drugbanksmall molecule
DB08059 WortmanninDrugbanksmall molecule
DB11772 PilaralisibDrugbanksmall molecule
DB12015 AlpelisibDrugbanksmall molecule
DB12483 CopanlisibDrugbanksmall molecule

Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
PK3CA_HUMANIRS1_HUMANBioGRID, IntAct, MINT12933652 14511371 16150444 16354680 23604317 23643389 27684187 details
PK3CA_HUMANP85A_HUMANBioGRID, DIP, HPRD, IntAct, MINT11526404 15377662 15932879 16043515 16135792 18079394 19117013 19574958 19805105 20018188 20713702 22402981 23643389 24657164 25253337 26475863 26496610 26839216 27684187 28205554 32814053 7929193 7957566 9235916 9565634 details
PK3CA_HUMANAMBP_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANATIF1_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANSYVM_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANDDX5_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANDNJB6_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANFRIL_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANITIH1_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANCASL_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANRS20_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANSQSTM_HUMANBioGRID, IntAct18624398 27684187 details
PK3CA_HUMANUFD1_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANGRB2_HUMANBioGRID, IntAct19380743 21706016 28514442 32814053 9565634 details
PK3CA_HUMANP55G_HUMANBioGRID, HPRD, IntAct22402981 25814554 26496610 28514442 9415396 details
PK3CA_HUMANDP13A_HUMANBioGRID, HPRD, IntAct10490823 25241761 details
PK3CA_HUMANFANCC_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANGLT12_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANRASH_HUMANBioGRID, HPRD, MINT10783161 14724584 24412244 8665852 9150145 details
PK3CA_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANF16P2_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANTMOD1_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANTNF13_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANUMPS_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANBEX1_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANBEX2_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANI13R2_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANIL24_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANHOP2_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANIL3RB_HUMANDIP23526884 details
PK3CA_HUMANFOS_HUMANIntAct32814053 details
PK3CA_HUMANHD_HUMANIntAct32814053 details
PK3CA_HUMANATX3_HUMANIntAct32814053 details
PK3CA_HUMANATX1_HUMANIntAct32814053 details
PK3CA_HUMANATR_HUMANBioGRID10608806 details
PK3CA_HUMANGRP3_HUMANBioGRID15213298 details
PK3CA_HUMANRHES_HUMANBioGRID, HPRD14724584 16757351 details
PK3CA_HUMANLCK_HUMANBioGRID, HPRD14583609 8020561 8246987 details
PK3CA_HUMANADAP1_HUMANBioGRID12893243 details
PK3CA_HUMANDGKZ_HUMANBioGRID12890670 details
PK3CA_HUMANRASK_HUMANBioGRID10783161 34079125 details
PK3CA_HUMANSGK1_HUMANBioGRID10357815 details
PK3CA_HUMANTNFL6_HUMANBioGRID19807924 details
PK3CA_HUMANSTAT1_HUMANBioGRID11438544 details
PK3CA_HUMANSMAD2_HUMANBioGRID16806069 details
PK3CA_HUMANSMAD3_HUMANBioGRID16806069 details
PK3CA_HUMANAKT1_HUMANBioGRID19117013 21041639 21816939 25793261 details
PK3CA_HUMANPDK1_HUMANBioGRID21041639 details
PK3CA_HUMANCYH3_HUMANBioGRID21041639 details
PK3CA_HUMANCYH2_HUMANBioGRID21041639 details
PK3CA_HUMANPGFRA_HUMANBioGRID7682895 details
PK3CA_HUMANCSF1R_HUMANBioGRID9380408 details
PK3CA_HUMANNED4L_HUMANBioGRID27339899 details
PK3CA_HUMANEGFR_HUMANBioGRID1845983 25754235 28205554 31959764 8561895 details
PK3CA_HUMANSNX9_HUMANBioGRID17242350 details
PK3CA_HUMANPTN11_HUMANBioGRID26839216 9565634 9660791 details
PK3CA_HUMANTF65_HUMANBioGRID15932879 details
PK3CA_HUMANARAF_HUMANBioGRID28205554 details
PK3CA_HUMANCCND2_HUMANBioGRID28205554 details
PK3CA_HUMANGLIS2_HUMANBioGRID28205554 details
PK3CA_HUMANMYC_HUMANBioGRID28205554 details
PK3CA_HUMANSTK11_HUMANBioGRID28205554 details
PK3CA_HUMANERBB3_HUMANBioGRID, IntAct11546794 19411071 24189400 details
PK3CA_HUMANP85B_HUMANBioGRID, DIP, IntAct19380743 22402981 23604317 25253337 26496610 27684187 details
PK3CA_HUMANCBL_HUMANBioGRID, IntAct11157475 19380743 9119889 details
PK3CA_HUMANPLCG1_HUMANBioGRID, IntAct31585087 8561895 details
PK3CA_HUMANNOTC1_HUMANBioGRID14583609 details
PK3CA_HUMANARHG1_HUMANBioGRID12754211 details
PK3CA_HUMANGNAQ_HUMANBioGRID, HPRD12704201 details
PK3CA_HUMANGELS_HUMANBioGRID11577104 details
PK3CA_HUMAN1433F_HUMANBioGRID11969417 details
PK3CA_HUMANIRS4_HUMANBioGRID, HPRD11912194 details
PK3CA_HUMANUBF1_HUMANBioGRID17332342 details
PK3CA_HUMANWDR5_HUMANBioGRID21531708 details
PK3CA_HUMANTNR1A_HUMANBioGRID15707590 details
PK3CA_HUMANCD28_HUMANBioGRID9915850 details
PK3CA_HUMANIRS2_HUMANBioGRID, HPRD12933652 25879670 9113989 details
PK3CA_HUMANTNR5_HUMANBioGRID12637493 details
PK3CA_HUMANESR1_HUMANBioGRID11029009 24051437 details
PK3CA_HUMANGBB1_HUMANBioGRID19117013 details
PK3CA_HUMANKIT_HUMANBioGRID7691885 details
PK3CA_HUMANRAC1_HUMANBioGRID25819133 details
PK3CA_HUMANPTTG1_HUMANBioGRID15845362 details
PK3CA_HUMANDERL1_HUMANBioGRID28178653 details
PK3CA_HUMANRASN_HUMANBioGRID, HPRD30639242 7820549 8665852 details
PK3CA_HUMANRPGF5_HUMANBioGRID8561895 details
PK3CA_HUMANTRAF6_HUMANBioGRID29729098 details
PK3CA_HUMANPGFRB_HUMANHPRD8702949 details
PK3CA_HUMANKPCD_HUMANHPRD11676480 details
PK3CA_HUMANSH3K1_HUMANHPRD10921882 details
PK3CA_HUMANRASM_HUMANHPRD10803462 details
PK3CA_HUMANGBRB1_HUMANHPRD11606067 details
PK3CA_HUMANAPLP2_HUMANHPRD10490823 details
PK3CA_HUMANIL3_HUMANHPRD9113989 details
PK3CA_HUMANTCAM1_HUMANHPRD15940673 details
PK3CA_HUMANKS6B1_HUMANHPRD11279232 details
PK3CA_HUMANNMDE2_HUMANHPRD10620012 details