Entity Details

Primary name CASP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42575
EntryNameCASP2_HUMAN
FullNameCaspase-2
TaxID9606
Evidenceevidence at protein level
Length452
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesCASP2

GO terms

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GOName
GO:0001554 luteolysis
GO:0003407 neural retina development
GO:0004197 cysteine-type endopeptidase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007420 brain development
GO:0007568 aging
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016020 membrane
GO:0016485 protein processing
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0035234 ectopic germ cell programmed cell death
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site
IPR035702 Caspase-2FamilyFamily

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
CASP2_HUMANCRADD_HUMANBioGRID, HPRD, IntAct, MINT11156409 11832478 15073321 16652156 23049853 25416956 27107012 29875129 31467278 31515488 32296183 8985253 details
CASP2_HUMANCASP2_HUMANBioGRID, HPRD, IntAct, MINT11156409 11832478 22531785 25416956 26871637 29875129 31515488 32296183 9261102 details
CASP2_HUMANRL30_HUMANBioGRID, IntAct21988832 details
CASP2_HUMANEF1A1_HUMANBioGRID, MINT21900206 details
CASP2_HUMANRAI1_HUMANBioGRID, MINT21900206 details
CASP2_HUMANRXRA_HUMANBioGRID, MINT21900206 details
CASP2_HUMANGRB2_HUMANBioGRID, MINT21900206 details
CASP2_HUMANMDM2_HUMANBioGRID, IntAct21726810 details
CASP2_HUMANBAG4_HUMANBioGRID, IntAct32296183 details
CASP2_HUMANAAKB2_HUMANBioGRID, IntAct32296183 details
CASP2_HUMANCASP3_HUMANBioGRID11399776 18723680 details
CASP2_HUMANCASP7_HUMANBioGRID, HPRD11399776 details
CASP2_HUMANBID_HUMANBioGRID, HPRD11399776 11832478 details
CASP2_HUMANCASP8_HUMANBioGRID11832478 8962078 details
CASP2_HUMANCASPA_HUMANBioGRID, HPRD8962078 details
CASP2_HUMANCCND3_HUMANBioGRID, HPRD12011445 details
CASP2_HUMANUBC9_HUMANBioGRID15882978 details
CASP2_HUMANSUMO1_HUMANBioGRID15882978 details
CASP2_HUMANBIRC2_HUMANBioGRID16701639 29875129 details
CASP2_HUMANRFXK_HUMANBioGRID29362422 details
CASP2_HUMANCIB1_HUMANBioGRID10745097 details
CASP2_HUMANPACA_HUMANHPRD11350957 11972030 details
CASP2_HUMANMZB1_HUMANHPRD11350957 11972030 details
CASP2_HUMANPIDD1_HUMANBioGRID, HPRD, IntAct15073321 16360037 16652156 21415862 details
CASP2_HUMANNOD1_HUMANBioGRID, HPRD10329646 details
CASP2_HUMANNLRP1_HUMANBioGRID, HPRD11076957 details
CASP2_HUMANNOL3_HUMANBioGRID, HPRD9560245 details
CASP2_HUMANTNR1A_HUMANBioGRID8985253 details
CASP2_HUMANCASPE_HUMANBioGRID, HPRD9792675 details
CASP2_HUMANCRYAB_HUMANBioGRID23049853 details
CASP2_HUMANTRAF1_HUMANBioGRID29875129 details
CASP2_HUMANTRAF2_HUMANBioGRID29875129 details
CASP2_HUMANTRAF3_HUMANBioGRID29875129 details
CASP2_HUMANHTRA2_HUMANBioGRID29875129 details
CASP2_HUMANIMA1_HUMANHPRD12477715 details
CASP2_HUMANGOGA3_HUMANHPRD10791974 details
CASP2_HUMANDCTN1_HUMANHPRD11425872 details
CASP2_HUMANCSK21_HUMANHPRD16193064 details
CASP2_HUMANCFLAR_HUMANHPRD9228018 details
CASP2_HUMANRB_HUMANHPRD15735701 details
CASP2_HUMANDESP_HUMANHPRD15500642 details