Entity Details

Primary name ECE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42892
EntryNameECE1_HUMAN
FullNameEndothelin-converting enzyme 1
TaxID9606
Evidenceevidence at protein level
Length770
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesECE1

GO terms

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GOName
GO:0001921 positive regulation of receptor recycling
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007507 heart development
GO:0008270 zinc ion binding
GO:0009897 external side of plasma membrane
GO:0010814 substance P catabolic process
GO:0010815 bradykinin catabolic process
GO:0010816 calcitonin catabolic process
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0017046 peptide hormone binding
GO:0019229 regulation of vasoconstriction
GO:0031302 intrinsic component of endosome membrane
GO:0031982 vesicle
GO:0033093 Weibel-Palade body
GO:0034959 endothelin maturation
GO:0042447 hormone catabolic process
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0043583 ear development
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000718 Peptidase M13FamilyFamily
IPR008753 Peptidase M13, N-terminal domainDomainDomain
IPR018497 Peptidase M13, C-terminal domainDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR029734 Endothelin-converting enzyme 1FamilyFamily
IPR042089 Peptidase M13, domain 2FamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613870 OMIMHirschsprung disease, cardiac defects, and autonomic dysfunction (HCAD)A disorder characterized by skip-lesions Hirschsprung disease, craniofacial abnormalities and other dysmorphic features, cardiac defects including ductus arteriosus, small subaortic ventricular septal defect, small atrial septal defect, and autonomic dysfunction. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB07171 5-(2-hydroxyethyl)nonane-1,9-diolDrugbanksmall molecule