Entity Details

Primary name EAA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43005
EntryNameEAA3_HUMAN
FullNameExcitatory amino acid transporter 3
TaxID9606
Evidenceevidence at protein level
Length524
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesSLC1A1

GO terms

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GOName
GO:0001662 behavioral fear response
GO:0001975 response to amphetamine
GO:0005253 anion channel activity
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005314 high-affinity glutamate transmembrane transporter activity
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006750 glutathione biosynthetic process
GO:0006801 superoxide metabolic process
GO:0006811 ion transport
GO:0006836 neurotransmitter transport
GO:0006882 cellular zinc ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007212 dopamine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007420 brain development
GO:0007613 memory
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0009986 cell surface
GO:0010460 positive regulation of heart rate
GO:0010467 gene expression
GO:0010842 retina layer formation
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0015813 L-glutamate transmembrane transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016595 glutamate binding
GO:0018105 peptidyl-serine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0022008 neurogenesis
GO:0030424 axon
GO:0030425 dendrite
GO:0030534 adult behavior
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032148 activation of protein kinase B activity
GO:0032279 asymmetric synapse
GO:0033229 cysteine transmembrane transporter activity
GO:0035633 maintenance of blood-brain barrier
GO:0036293 response to decreased oxygen levels
GO:0036475 neuron death in response to oxidative stress
GO:0042417 dopamine metabolic process
GO:0042802 identical protein binding
GO:0042883 cysteine transport
GO:0043025 neuronal cell body
GO:0043083 synaptic cleft
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043278 response to morphine
GO:0043524 negative regulation of neuron apoptotic process
GO:0043679 axon terminus
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0048514 blood vessel morphogenesis
GO:0048678 response to axon injury
GO:0050808 synapse organization
GO:0051938 L-glutamate import
GO:0055038 recycling endosome membrane
GO:0060013 righting reflex
GO:0060047 heart contraction
GO:0060291 long-term synaptic potentiation
GO:0061744 motor behavior
GO:0070062 extracellular exosome
GO:0070633 transepithelial transport
GO:0070777 D-aspartate transport
GO:0070778 L-aspartate transmembrane transport
GO:0070779 D-aspartate import across plasma membrane
GO:0071242 cellular response to ammonium ion
GO:0071288 cellular response to mercury ion
GO:0071314 cellular response to cocaine
GO:0071407 cellular response to organic cyclic compound
GO:0071577 zinc ion transmembrane transport
GO:0071944 cell periphery
GO:0072347 response to anesthetic
GO:0090313 regulation of protein targeting to membrane
GO:0090461 glutamate homeostasis
GO:0097049 motor neuron apoptotic process
GO:0097386 glial cell projection
GO:0097440 apical dendrite
GO:0098712 L-glutamate import across plasma membrane
GO:0098793 presynapse
GO:0098877 neurotransmitter receptor transport to plasma membrane
GO:0099544 perisynaptic space
GO:0140009 L-aspartate import across plasma membrane
GO:0140010 D-aspartate transmembrane transporter activity
GO:0150002 distal dendrite
GO:0150104 transport across blood-brain barrier
GO:1902476 chloride transmembrane transport
GO:1990635 proximal dendrite
GO:1990708 conditioned place preference

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell junction
Cell membrane
Early endosome membrane
Late endosome membrane
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR001991 Sodium:dicarboxylate symporterFamilyFamily
IPR018107 Sodium:dicarboxylate symporter, conserved siteSiteConserved site
IPR036458 Sodium:dicarboxylate symporter superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
222730 OMIMDicarboxylic aminoaciduria (DCBXA)An autosomal recessive disorder characterized by abnormal excretion of urinary glutamate and aspartate, resulting from the incomplete reabsorption of anionic amino acids from the glomerular filtrate in the kidney. It can be associated with mental retardation. The disease is caused by variants affecting the gene represented in this entry.
615232 OMIMSchizophrenia 18 (SCZD18)A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Disease susceptibility is associated with variants affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed:21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed:23341099).

Drugs

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DrugNameSourceType
DB00128 Aspartic acidDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB00230 PregabalinDrugbanksmall molecule