Entity Details

Primary name LIS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43034
EntryNameLIS1_HUMAN
FullNamePlatelet-activating factor acetylhydrolase IB subunit beta
TaxID9606
Evidenceevidence at protein level
Length410
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPAFAH1B1

GO terms

Show/Hide Table
GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000132 establishment of mitotic spindle orientation
GO:0000226 microtubule cytoskeleton organization
GO:0000235 astral microtubule
GO:0000776 kinetochore
GO:0001675 acrosome assembly
GO:0001764 neuron migration
GO:0005635 nuclear envelope
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005875 microtubule associated complex
GO:0005881 cytoplasmic microtubule
GO:0005938 cell cortex
GO:0007017 microtubule-based process
GO:0007052 mitotic spindle organization
GO:0007097 nuclear migration
GO:0007268 chemical synaptic transmission
GO:0007281 germ cell development
GO:0007405 neuroblast proliferation
GO:0007611 learning or memory
GO:0008017 microtubule binding
GO:0008090 retrograde axonal transport
GO:0008201 heparin binding
GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex
GO:0008344 adult locomotory behavior
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0016042 lipid catabolic process
GO:0019226 transmission of nerve impulse
GO:0021540 corpus callosum morphogenesis
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0021987 cerebral cortex development
GO:0030036 actin cytoskeleton organization
GO:0031023 microtubule organizing center organization
GO:0031514 motile cilium
GO:0031965 nuclear membrane
GO:0034452 dynactin binding
GO:0038026 reelin-mediated signaling pathway
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043274 phospholipase binding
GO:0045202 synapse
GO:0046469 platelet activating factor metabolic process
GO:0046982 protein heterodimerization activity
GO:0047496 vesicle transport along microtubule
GO:0048471 perinuclear region of cytoplasm
GO:0048854 brain morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0051010 microtubule plus-end binding
GO:0051012 microtubule sliding
GO:0051219 phosphoprotein binding
GO:0051301 cell division
GO:0070062 extracellular exosome
GO:0070840 dynein complex binding
GO:0097711 ciliary basal body-plasma membrane docking
GO:1904115 axon cytoplasm
GO:2000574 obsolete regulation of microtubule motor activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR006594 LIS1 homology motifDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017252 Dynein regulator LIS1FamilyFamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR037190 LIS1, N-terminalFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
607432 OMIMLissencephaly 1 (LIS1)A classical lissencephaly. It is characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. The cortex is abnormally thick and poorly organized with 4 primitive layers. Associated with enlarged and dysmorphic ventricles and often hypoplasia of the corpus callosum. The disease is caused by variants affecting the gene represented in this entry.
607432 OMIMLissencephaly 1 (LIS1)A classical lissencephaly. It is characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. The cortex is abnormally thick and poorly organized with 4 primitive layers. Associated with enlarged and dysmorphic ventricles and often hypoplasia of the corpus callosum. The disease is caused by variants affecting the gene represented in this entry.
247200 OMIMMiller-Dieker lissencephaly syndrome (MDLS)A contiguous gene deletion syndrome of chromosome 17p13.3, characterized by classical lissencephaly and distinct facial features. Additional congenital malformations can be part of the condition. The disease is caused by variants affecting the gene represented in this entry.

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
LIS1_HUMANSYK_HUMANBioGRID, HPRD, IntAct16169070 details
LIS1_HUMANNDEL1_HUMANBioGRID, HPRD, IntAct, UniProt10931877 11163260 12796778 12885786 14970193 19622634 27173435 28514442 31815665 unassigned1312 details
LIS1_HUMANDISC1_HUMANBioGRID, IntAct, MINT17043677 29961565 31413325 details
LIS1_HUMANDYHC1_HUMANBioGRID, IntAct11889140 12885786 18784752 19622634 26344197 26496610 27173435 34079125 unassigned1312 details
LIS1_HUMANNDE1_HUMANBioGRID, HPRD, IntAct10931877 11163258 12885786 27173435 34079125 unassigned1312 details
LIS1_HUMANPA1B2_HUMANBioGRID, HPRD, IntAct10727864 12885786 19622634 27173435 unassigned1312 details
LIS1_HUMANPA1B3_HUMANBioGRID, HPRD, IntAct10727864 19622634 26186194 28514442 details
LIS1_HUMANNUDC3_HUMANBioGRID, DIP16754861 details
LIS1_HUMANHS90A_HUMANBioGRID, DIP20133715 20675372 details
LIS1_HUMANTNIK_HUMANBioGRID, IntAct17043677 31413325 details
LIS1_HUMANCSK21_HUMANBioGRID, HPRD10491172 details
LIS1_HUMANNUDC_HUMANBioGRID, HPRD11734602 12885786 20675372 34079125 9601647 details
LIS1_HUMANTBA1A_HUMANBioGRID, HPRD9384577 details
LIS1_HUMANLIS1_HUMANBioGRID, HPRD11889140 12885786 16258276 details
LIS1_HUMANDCTN2_HUMANBioGRID11889140 details
LIS1_HUMANDCX_HUMANBioGRID, HPRD11001923 12885786 details
LIS1_HUMANCLIP1_HUMANBioGRID, HPRD11940666 12885786 34079125 details
LIS1_HUMANKTNA1_HUMANBioGRID16203747 details
LIS1_HUMANKTNB1_HUMANBioGRID16203747 details
LIS1_HUMANPDE4D_HUMANBioGRID21652625 details
LIS1_HUMANFBX7_HUMANBioGRID27503909 details
LIS1_HUMANCENPF_HUMANIntAct17600710 details
LIS1_HUMANDCTN1_HUMANBioGRID, HPRD, IntAct11056532 11889140 14584027 26638075 27173435 unassigned1312 details
LIS1_HUMANDYLT1_HUMANBioGRID, IntAct27173435 unassigned1312 details
LIS1_HUMANDLRB2_HUMANBioGRID, IntAct27173435 unassigned1312 details
LIS1_HUMANGID8_HUMANBioGRID, IntAct27173435 unassigned1312 details
LIS1_HUMANMARE1_HUMANBioGRID, IntAct22863883 27173435 unassigned1312 details
LIS1_HUMANDC1I2_HUMANBioGRID, IntAct27173435 34079125 unassigned1312 details
LIS1_HUMANDC1L1_HUMANBioGRID, IntAct27173435 34079125 unassigned1312 details
LIS1_HUMANDYLT3_HUMANBioGRID, IntAct27173435 unassigned1312 details
LIS1_HUMANMARE2_HUMANBioGRID, IntAct27173435 unassigned1312 details
LIS1_HUMANAHI1_HUMANBioGRID, IntAct27173435 unassigned1312 details
LIS1_HUMANDYT2B_HUMANBioGRID, IntAct27173435 unassigned1312 details
LIS1_HUMANNUDC2_HUMANBioGRID, DIP20133715 details
LIS1_HUMANWDR5_HUMANBioGRID17041588 details
LIS1_HUMANDYL1_HUMANBioGRID11056532 details
LIS1_HUMANDC1I1_HUMANBioGRID18784752 19622634 21652625 details
LIS1_HUMANPDE4B_HUMANBioGRID21652625 details
LIS1_HUMANBICD2_HUMANBioGRID22956769 details
LIS1_HUMANDCDC1_HUMANBioGRID22159412 details
LIS1_HUMANDAB1_HUMANHPRD14578885 details
LIS1_HUMANDNAI1_HUMANHPRD11889140 details
LIS1_HUMANHS105_HUMANHPRD14733918 details
LIS1_HUMANMAP1B_HUMANHPRD15762842 details