Entity Details

Primary name CATK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43235
EntryNameCATK_HUMAN
FullNameCathepsin K
TaxID9606
Evidenceevidence at protein level
Length329
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesCTSK

GO terms

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GOName
GO:0000422 autophagy of mitochondrion
GO:0001968 fibronectin binding
GO:0002224 toll-like receptor signaling pathway
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005764 lysosome
GO:0006508 proteolysis
GO:0006590 thyroid hormone generation
GO:0006955 immune response
GO:0008234 cysteine-type peptidase activity
GO:0016324 apical plasma membrane
GO:0022617 extracellular matrix disassembly
GO:0030574 collagen catabolic process
GO:0036021 endolysosome lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043394 proteoglycan binding
GO:0045616 regulation of keratinocyte differentiation
GO:0051603 proteolysis involved in cellular protein catabolic process

Subcellular Location

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Subcellular Location
Apical cell membrane
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR000668 Peptidase C1A, papain C-terminalDomainDomain
IPR013201 Cathepsin propeptide inhibitor domain (I29)DomainDomain
IPR015644 Peptidase C1A, cathepsin KFamilyFamily
IPR025660 Cysteine peptidase, histidine active siteSiteActive site
IPR025661 Cysteine peptidase, asparagine active siteSiteActive site
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR039417 Papain-like cysteine endopeptidaseDomainDomain

Diseases

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Disease IDSourceNameDescription
265800 OMIMPycnodysostosis (PKND)A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01858 [1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]PentylcarbamateDrugbanksmall molecule
DB02679 CyanamideDrugbanksmall molecule
DB02869 3-amino-5-phenylpentaneDrugbanksmall molecule
DB03405 N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamideDrugbanksmall molecule
DB03456 N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamideDrugbanksmall molecule
DB03642 N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamideDrugbanksmall molecule
DB03891 Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamateDrugbanksmall molecule
DB04234 N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-LeucinamideDrugbanksmall molecule
DB04244 (2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamideDrugbanksmall molecule
DB04523 Tert-Butyl(1s)-1-Cyclohexyl-2-OxoethylcarbamateDrugbanksmall molecule
DB05736 MIV-701Drugbanksmall molecule
DB06367 RelacatibDrugbanksmall molecule
DB06670 OdanacatibDrugbanksmall molecule
DB07563 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamineDrugbanksmall molecule
DB07592 (2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamateDrugbanksmall molecule
DB07593 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATEDrugbanksmall molecule
DB07965 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrileDrugbanksmall molecule
DB07967 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILEDrugbanksmall molecule
DB08270 N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDEDrugbanksmall molecule
DB08287 (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamideDrugbanksmall molecule
DB08594 TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATEDrugbanksmall molecule
DB15599 MIV-711Drugbanksmall molecule