Entity Details

Primary name ZAP70_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43403
EntryNameZAP70_HUMAN
FullNameTyrosine-protein kinase ZAP-70
TaxID9606
Evidenceevidence at protein level
Length619
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesZAP70

GO terms

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GOName
GO:0001772 immunological synapse
GO:0001784 phosphotyrosine residue binding
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030217 T cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0035556 intracellular signal transduction
GO:0042101 T cell receptor complex
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0043366 beta selection
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045087 innate immune response
GO:0045582 positive regulation of T cell differentiation
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046777 protein autophosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0070489 T cell aggregation
GO:0072678 T cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamilyFamilyHomologous superfamily
IPR035838 SYK/ZAP-70, N-terminal SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02010 StaurosporineDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
ZAP70_HUMANLCK_HUMANBioGRID, HPRD, IntAct, MINT10318843 10556826 15144186 16461343 22242145 7539035 7961936 8798643 9685404 details
ZAP70_HUMANSHC1_HUMANBioGRID, HPRD, MINT15688026 23267066 7961936 8235613 8761298 9685404 details
ZAP70_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
ZAP70_HUMANEGFR_HUMANBioGRID, IntAct, MINT16273093 22973453 24658140 25402006 31980649 details
ZAP70_HUMANPTN22_HUMANBioGRID, HPRD, IntAct16461343 details
ZAP70_HUMANCD3Z_HUMANBioGRID, DIP, HPRD, MINT, UniProt10704231 10752619 11353765 15832366 20637659 21957439 22242145 24463463 26390156 30863395 7509083 7528772 7737297 8366117 8647168 8648092 8901551 8906806 9036949 9185620 details
ZAP70_HUMANCRK_HUMANBioGRID, HPRD, MINT10419455 16339550 details
ZAP70_HUMANCD3E_HUMANBioGRID, HPRD, MINT11855827 7761456 8366117 8647168 8906806 details
ZAP70_HUMANVAV_HUMANBioGRID, HPRD, MINT16339550 7798261 8530437 9151714 details
ZAP70_HUMANNDUB8_HUMANBioGRID, IntAct21988832 details
ZAP70_HUMANNR0B2_HUMANBioGRID, IntAct21988832 details
ZAP70_HUMANASB3_HUMANBioGRID, IntAct21988832 details
ZAP70_HUMANAPC11_HUMANBioGRID, IntAct21988832 details
ZAP70_HUMANKIT_HUMANBioGRID, IntAct24728074 details
ZAP70_HUMANMET_HUMANBioGRID, IntAct24728074 details
ZAP70_HUMANLCP2_HUMANBioGRID, HPRD, IntAct10660534 12190313 24584089 8702662 9047237 details
ZAP70_HUMANTHMS1_HUMANIntAct23460737 details
ZAP70_HUMANCBL_HUMANBioGRID, DIP, HPRD10074432 10078535 10779765 11133830 11353765 16503409 22266821 29053960 8798643 9407100 9988730 details
ZAP70_HUMANLRRK2_HUMANBioGRID, IntAct29513927 details
ZAP70_HUMANDAPK1_HUMANBioGRID, IntAct29513927 details
ZAP70_HUMANDBNL_HUMANBioGRID, HPRD14557276 details
ZAP70_HUMAN3BP2_HUMANBioGRID, HPRD11390470 9846481 details
ZAP70_HUMANSHB_HUMANBioGRID, HPRD12084069 details
ZAP70_HUMANLAT_HUMANBioGRID, HPRD11368773 12186560 16906159 23514740 details
ZAP70_HUMANPHAG1_HUMANBioGRID, HPRD10790433 details
ZAP70_HUMANPLCG1_HUMANBioGRID, HPRD16467851 7629168 8906806 details
ZAP70_HUMANPTN6_HUMANBioGRID, HPRD10458769 8638162 details
ZAP70_HUMANFCRL3_HUMANBioGRID, HPRD12051764 details
ZAP70_HUMANTYOBP_HUMANBioGRID, HPRD9490415 details
ZAP70_HUMANTBA1A_HUMANBioGRID8530437 details
ZAP70_HUMANCBLC_HUMANBioGRID22888118 details
ZAP70_HUMANA4_HUMANBioGRID21832049 details
ZAP70_HUMANCSK_HUMANBioGRID8621646 details
ZAP70_HUMANRNF41_HUMANBioGRID26390156 details
ZAP70_HUMANUBP2_HUMANBioGRID26936881 details
ZAP70_HUMANERBB2_HUMANBioGRID22973453 details
ZAP70_HUMANERBB4_HUMANBioGRID22973453 details
ZAP70_HUMANHS90A_HUMANMINT16888650 details
ZAP70_HUMANCBLB_HUMANBioGRID, HPRD10074432 21453975 details
ZAP70_HUMANSLAP1_HUMANBioGRID, HPRD10449770 details
ZAP70_HUMANFYN_HUMANBioGRID, HPRD7760813 details
ZAP70_HUMANABL1_HUMANBioGRID, HPRD7760813 details
ZAP70_HUMANRASA1_HUMANBioGRID, HPRD7760813 details
ZAP70_HUMANPPAC_HUMANBioGRID, HPRD11976341 details
ZAP70_HUMANGAB2_HUMANBioGRID, HPRD11572860 details
ZAP70_HUMANGRB2_HUMANBioGRID, HPRD23267066 7629168 details
ZAP70_HUMANSLAP2_HUMANBioGRID, HPRD11891219 details
ZAP70_HUMANSIT1_HUMANBioGRID, HPRD10209036 details
ZAP70_HUMANCD4_HUMANBioGRID7539035 details
ZAP70_HUMANCD5_HUMANBioGRID, HPRD9378960 details
ZAP70_HUMANTBA1B_HUMANBioGRID15084271 details
ZAP70_HUMANTBB5_HUMANBioGRID8530437 details
ZAP70_HUMANHSP74_HUMANBioGRID16888650 details
ZAP70_HUMANP85A_HUMANBioGRID15536084 details
ZAP70_HUMANCD38_HUMANBioGRID14523017 details
ZAP70_HUMANZAP70_HUMANBioGRID, HPRD10037717 15144186 30863395 7961936 8798643 8906806 details
ZAP70_HUMANPEAR1_HUMANBioGRID22993420 details
ZAP70_HUMANSHC3_HUMANBioGRID22242145 details
ZAP70_HUMANCD3D_HUMANBioGRID30863395 8647168 details
ZAP70_HUMANCD3G_HUMANBioGRID30863395 8647168 details
ZAP70_HUMANUBS3A_HUMANBioGRID31659016 details
ZAP70_HUMANSOS1_HUMANHPRD7629168 details
ZAP70_HUMANTBA4A_HUMANHPRD8530437 details
ZAP70_HUMANDUS3_HUMANHPRD12447358 details
ZAP70_HUMANFAK2_HUMANHPRD10867021 details
ZAP70_HUMANSH2B3_HUMANHPRD9169414 details
ZAP70_HUMANSLAF6_HUMANHPRD8756661 details
ZAP70_HUMANPTN3_HUMANHPRD14672952 15588985 details
ZAP70_HUMANNFAM1_HUMANHPRD15143214 details
ZAP70_HUMANMUC1_HUMANHPRD14766232 details
ZAP70_HUMANPRLR_HUMANHPRD10221598 details
ZAP70_HUMANINAR1_HUMANHPRD9403695 details
ZAP70_HUMANCD79B_HUMANHPRD12393534 details
ZAP70_HUMANTBB2A_HUMANHPRD8530437 details
ZAP70_HUMANWIPF1_HUMANHPRD12504004 details
ZAP70_HUMANCAR11_HUMANHPRD12154360 details
ZAP70_HUMANLAX1_HUMANHPRD12359715 details
ZAP70_HUMANDEFI6_HUMANHPRD12648457 details
ZAP70_HUMANFCG3A_HUMANHPRD7819147 details
ZAP70_HUMANPTPRC_HUMANHPRD7737297 details