Entity Details

Primary name TNR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43489
EntryNameTNR4_HUMAN
FullNameTumor necrosis factor receptor superfamily member 4
TaxID9606
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesTNFRSF4

GO terms

Show/Hide Table
GOName
GO:0001618 virus receptor activity
GO:0002639 positive regulation of immunoglobulin production
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030890 positive regulation of B cell proliferation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042098 T cell proliferation
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated

Subcellular Location

Show/Hide Table
Subcellular Location
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR020445 Tumour necrosis factor receptor 4FamilyFamily
IPR034022 Tumour necrosis factor receptor 4, N-terminalDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
615593 OMIMImmunodeficiency 16 (IMD16)An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency. The disease is caused by variants affecting the gene represented in this entry.