Entity Details

Primary name 3HAO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46952
EntryName3HAO_HUMAN
FullName3-hydroxyanthranilate 3,4-dioxygenase
TaxID9606
Evidenceevidence at protein level
Length286
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesHAAO

GO terms

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GOName
GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006569 tryptophan catabolic process
GO:0008198 ferrous iron binding
GO:0009055 electron transfer activity
GO:0009435 NAD biosynthetic process
GO:0010043 response to zinc ion
GO:0019805 quinolinate biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0043420 anthranilate metabolic process
GO:0046686 response to cadmium ion
GO:0046874 quinolinate metabolic process
GO:0070050 neuron cellular homeostasis

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR010329 3-hydroxyanthranilic acid dioxygenaseFamilyFamily
IPR011051 RmlC-like cupin domain superfamilyFamilyHomologous superfamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR016700 3-hydroxyanthranilate 3, 4-dioxygenase, metazoanFamilyFamily

Diseases

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Disease IDSourceNameDescription
617660 OMIMVertebral, cardiac, renal, and limb defects syndrome 1 (VCRL1)An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
3HAO_HUMANDCE1_HUMANBioGRID, HPRD, IntAct16189514 25416956 31515488 32296183 details
3HAO_HUMANGDIR1_HUMANBioGRID, MINT21900206 details
3HAO_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
3HAO_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details