Entity Details

Primary name SYQ_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP47897
EntryNameSYQ_HUMAN
FullNameGlutamine--tRNA ligase
TaxID9606
Evidenceevidence at protein level
Length775
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesQARS1

GO terms

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GOName
GO:0004819 glutamine-tRNA ligase activity
GO:0004860 protein kinase inhibitor activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006425 glutaminyl-tRNA aminoacylation
GO:0006469 negative regulation of protein kinase activity
GO:0007420 brain development
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0019901 protein kinase binding
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0032991 protein-containing complex
GO:0045892 negative regulation of transcription, DNA-templated
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000924 Glutamyl/glutaminyl-tRNA synthetaseFamilyFamily
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR004514 Glutamine-tRNA synthetaseFamilyFamily
IPR007638 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2DomainDomain
IPR007639 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminalDomainDomain
IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamilyFamilyHomologous superfamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, N-terminalFamilyHomologous superfamily
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domainDomainDomain
IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domainDomainDomain
IPR042558 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1FamilyHomologous superfamily
IPR042559 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2FamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615760 OMIMMicrocephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA)A severe, autosomal recessive, neurodevelopmental and neurodegenerative disorder characterized by progressive microcephaly, severe seizures in infancy, atrophy of the cerebral cortex and cerebellar vermis, and mild atrophy of the cerebellar hemispheres, resulting in profoundly delayed development and hypotonia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00130 L-GlutamineDrugbanksmall molecule

Interactions

109 interactions

InteractorPartnerSourcesPublicationsLink
SYQ_HUMANHS90A_HUMANMINT10913161 details
SYQ_HUMANPRC2A_HUMANBioGRID, HPRD, IntAct14667819 details
SYQ_HUMANRNF11_HUMANBioGRID, HPRD, IntAct, MINT15231748 21988832 31985874 32296183 32814053 details
SYQ_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
SYQ_HUMANCPNE3_HUMANBioGRID, HPRD, IntAct16169070 details
SYQ_HUMANDUS11_HUMANBioGRID, HPRD, IntAct16169070 details
SYQ_HUMANAIMP2_HUMANBioGRID, IntAct, MINT21285945 22863883 22939629 26344197 28514442 31792442 9878398 details
SYQ_HUMANCLH1_HUMANBioGRID, IntAct21988832 details
SYQ_HUMANIRF1_HUMANBioGRID, IntAct21988832 details
SYQ_HUMANANXA7_HUMANBioGRID, MINT21900206 details
SYQ_HUMANCDK4_HUMANBioGRID, MINT21900206 details
SYQ_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
SYQ_HUMANDPPA4_HUMANBioGRID, MINT21900206 details
SYQ_HUMANF118B_HUMANBioGRID, MINT21900206 details
SYQ_HUMANGA45A_HUMANBioGRID, MINT21900206 details
SYQ_HUMANGSK3B_HUMANBioGRID, MINT21900206 30711629 details
SYQ_HUMANH2AX_HUMANBioGRID, MINT21900206 details
SYQ_HUMANKCNE3_HUMANBioGRID, MINT21900206 details
SYQ_HUMANLTOR3_HUMANBioGRID, MINT21900206 details
SYQ_HUMANP55G_HUMANBioGRID, MINT21900206 details
SYQ_HUMANPIN1_HUMANBioGRID, MINT21900206 details
SYQ_HUMANSMN_HUMANBioGRID, MINT21900206 details
SYQ_HUMANSTK3_HUMANBioGRID, MINT21900206 details
SYQ_HUMANKITH_HUMANBioGRID, MINT21900206 details
SYQ_HUMANT22D1_HUMANBioGRID, MINT21900206 details
SYQ_HUMANTTHY_HUMANBioGRID, MINT21900206 details
SYQ_HUMANTLE5_HUMANBioGRID, IntAct25416956 details
SYQ_HUMANPCH2_HUMANBioGRID, IntAct25416956 32296183 details
SYQ_HUMANKLC3_HUMANBioGRID, IntAct25416956 details
SYQ_HUMANDTX2_HUMANBioGRID, IntAct21516116 25416956 details
SYQ_HUMANHTF4_HUMANBioGRID, IntAct25416956 31515488 details
SYQ_HUMANLZTS2_HUMANBioGRID, IntAct25416956 32296183 details
SYQ_HUMANTRAF4_HUMANBioGRID, IntAct25416956 32296183 details
SYQ_HUMANVP37B_HUMANBioGRID, IntAct25416956 32296183 details
SYQ_HUMANEFHC2_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANPTN21_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANPRDM6_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANZMY12_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANCACO2_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANDISC1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANBIRC7_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANSPDE4_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANLZTS1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANREL_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANHES7_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANSF3B4_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANSPRE2_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANIKZF1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANTAD2A_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANCOG6_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANTRI27_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANNEBL_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANPPR32_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANHM20A_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANSP7_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANGPBP1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANTRI35_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANLEG9C_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANSLAP1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANLEG9B_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANB9D2_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANRED_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANMCCD1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANESS2_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANXIAP_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANNAB2_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANUSBP1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANVINEX_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANDYN2_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANEDC3_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
SYQ_HUMANMAAI_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANKRT36_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANTGM7_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANFA83A_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANF161A_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANNOXA1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANSHLD1_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANCTBP2_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANSPC1L_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANMESD_HUMANBioGRID, IntAct32296183 details
SYQ_HUMANACTN2_HUMANBioGRID, IntAct25910212 details
SYQ_HUMANSYRC_HUMANBioGRID, HPRD, IntAct10801842 22863883 22939629 26344197 28514442 details
SYQ_HUMANNLGN3_HUMANBioGRID, IntAct25464930 details
SYQ_HUMANGRN_HUMANIntAct32814053 details
SYQ_HUMANHSPB1_HUMANIntAct32814053 details
SYQ_HUMANWFS1_HUMANIntAct32814053 details
SYQ_HUMANKIF1B_HUMANIntAct32814053 details
SYQ_HUMANHD_HUMANIntAct32814053 details
SYQ_HUMANARLY_HUMANBioGRID, HPRD16189514 details
SYQ_HUMANA4_HUMANBioGRID21832049 details
SYQ_HUMANCCD33_HUMANBioGRID32296183 details
SYQ_HUMANM3K14_HUMANIntAct14743216 details
SYQ_HUMANIKKE_HUMANIntAct17353931 details
SYQ_HUMANPHLA3_HUMANIntAct17353931 details
SYQ_HUMANOFD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
SYQ_HUMANM3K5_HUMANBioGRID, HPRD11096076 details
SYQ_HUMANHDAC5_HUMANBioGRID21081666 details
SYQ_HUMANRN126_HUMANBioGRID26508657 details
SYQ_HUMANCA131_HUMANBioGRID26472760 details
SYQ_HUMANGTPB1_HUMANBioGRID29395067 details
SYQ_HUMANSHLD2_HUMANBioGRID30154076 details
SYQ_HUMANISG15_HUMANBioGRID33024031 details