Entity Details

Primary name TNFL6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48023
EntryNameTNFL6_HUMAN
FullNameTumor necrosis factor ligand superfamily member 6
TaxID9606
Evidenceevidence at protein level
Length281
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesFASLG

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0005102 signaling receptor binding
GO:0005123 death receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006925 inflammatory cell apoptotic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell population proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009897 external side of plasma membrane
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0030644 cellular chloride ion homeostasis
GO:0032496 response to lipopolysaccharide
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043202 lysosomal lumen
GO:0043525 positive regulation of neuron apoptotic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666 retinal cell programmed cell death
GO:0048388 endosomal lumen acidification
GO:0048471 perinuclear region of cytoplasm
GO:0060205 cytoplasmic vesicle lumen
GO:0070062 extracellular exosome
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070848 response to growth factor
GO:0071346 cellular response to interferon-gamma
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum
GO:1905782 positive regulation of phosphatidylserine exposure on apoptotic cell surface
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle lumen
Lysosome lumen
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR006052 Tumour necrosis factor domainDomainDomain
IPR006053 Tumour necrosis factorFamilyFamily
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site
IPR028326 Tumor necrosis factor ligand superfamily member 6FamilyFamily

Diseases

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Disease IDSourceNameDescription
601859 OMIMAutoimmune lymphoproliferative syndrome 1A (ALPS1A)A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

97 interactions

InteractorPartnerSourcesPublicationsLink
TNFL6_HUMANTNR6_HUMANBioGRID, DIP, HPRD, IntAct12753742 12887920 15659383 21803845 24025841 25241761 9126929 9228058 details
TNFL6_HUMANPACN2_HUMANBioGRID, HPRD, MINT12023017 16318909 details
TNFL6_HUMANPPIP1_HUMANHPRD, IntAct, MINT16204241 16318909 19807924 details
TNFL6_HUMANFNBP1_HUMANBioGRID, HPRD, MINT12023017 16318909 details
TNFL6_HUMANSRGP2_HUMANBioGRID, IntAct, MINT16318909 19807924 details
TNFL6_HUMANLYN_HUMANBioGRID, IntAct17164290 19807924 details
TNFL6_HUMANOSTF1_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSNX33_HUMANBioGRID, IntAct19807924 26186194 28514442 details
TNFL6_HUMANHCK_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANNCK1_HUMANBioGRID, DIP, HPRD, IntAct11741599 16595635 19807924 26871637 details
TNFL6_HUMANYES_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSRC_HUMANBioGRID, HPRD, IntAct11741599 19807924 details
TNFL6_HUMANSNX9_HUMANBioGRID, IntAct19807924 26186194 details
TNFL6_HUMANSRGP1_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSPD2B_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANBTK_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANES8L3_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANRHG09_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANMYO15_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANNCK2_HUMANBioGRID, IntAct19807924 32296183 details
TNFL6_HUMANFYB1_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANTEC_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSPTA1_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSAMN1_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSH3R2_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANDLG2_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANVINEX_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSKAP2_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANCRK_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSPN90_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSPD2A_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANBI2L1_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSH3G3_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANZO3_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANCACB3_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANMPP4_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANP85A_HUMANBioGRID, HPRD, IntAct11741599 19807924 25241761 details
TNFL6_HUMANDNMBP_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANDOCK4_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANKALRN_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANMACC1_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANSRGP3_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANFYN_HUMANBioGRID, HPRD, IntAct11741599 17164290 19807924 25241761 7589480 details
TNFL6_HUMANMIA_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANITSN2_HUMANBioGRID, IntAct19807924 22558309 details
TNFL6_HUMANNCF1_HUMANBioGRID, HPRD, IntAct11741599 19807924 details
TNFL6_HUMANITK_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANCACB4_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANRIM3C_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANFINC_HUMANBioGRID, HPRD, IntAct11276204 25241761 details
TNFL6_HUMANMMP7_HUMANBioGRID, HPRD, IntAct12464266 25241761 details
TNFL6_HUMANRGS20_HUMANBioGRID, IntAct25416956 32296183 details
TNFL6_HUMANTRIP6_HUMANBioGRID, IntAct25416956 details
TNFL6_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
TNFL6_HUMANNT2NA_HUMANBioGRID, IntAct25416956 details
TNFL6_HUMANSC23A_HUMANBioGRID, IntAct32296183 details
TNFL6_HUMANIHO1_HUMANBioGRID, IntAct32296183 details
TNFL6_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
TNFL6_HUMANKR123_HUMANBioGRID, IntAct32296183 details
TNFL6_HUMANTNS2_HUMANBioGRID, IntAct32296183 details
TNFL6_HUMANKT33B_HUMANBioGRID, IntAct32296183 details
TNFL6_HUMANECM1_HUMANBioGRID, IntAct32296183 details
TNFL6_HUMANKR111_HUMANBioGRID, IntAct32296183 details
TNFL6_HUMANTNFL6_HUMANDIP, NTNU12913110 21713032 details
TNFL6_HUMANTNF6B_HUMANBioGRID, DIP10318773 11994433 21300286 9872321 details
TNFL6_HUMANGRB2_HUMANBioGRID, HPRD11741599 12023017 12220636 details
TNFL6_HUMANLCK_HUMANBioGRID, HPRD11741599 details
TNFL6_HUMANGRAP_HUMANBioGRID, HPRD11741599 details
TNFL6_HUMANGRAP2_HUMANBioGRID, HPRD11741599 details
TNFL6_HUMANPTN13_HUMANBioGRID, HPRD16498403 9261095 details
TNFL6_HUMANFGR_HUMANBioGRID17164290 details
TNFL6_HUMANPK3CA_HUMANBioGRID19807924 details
TNFL6_HUMANNT2NC_HUMANBioGRID25416956 details
TNFL6_HUMANPDCD6_HUMANHPRD11606059 details
TNFL6_HUMANSUMO1_HUMANHPRD8906799 details
TNFL6_HUMANCASPA_HUMANBioGRID, IntAct, MINT12198154 15659383 16498403 details
TNFL6_HUMANCASP8_HUMANBioGRID, DIP, IntAct, MINT12198154 12753742 12887920 15659383 16498403 21803845 24025841 details
TNFL6_HUMANFADD_HUMANBioGRID, DIP, HPRD, IntAct, MINT12753742 12887920 15659383 16498403 21803845 24025841 25241761 details
TNFL6_HUMANPACN1_HUMANMINT16318909 details
TNFL6_HUMANPACN3_HUMANMINT16318909 details
TNFL6_HUMANCIP4_HUMANMINT16318909 details
TNFL6_HUMANRHG04_HUMANMINT16318909 details
TNFL6_HUMANSNX18_HUMANBioGRID, IntAct19807924 details
TNFL6_HUMANBID_HUMANBioGRID, IntAct15659383 25241761 details
TNFL6_HUMANMK08_HUMANBioGRID, IntAct15659383 25241761 details
TNFL6_HUMANTR10B_HUMANBioGRID15659383 details
TNFL6_HUMANEZRI_HUMANBioGRID, HPRD11013215 15659383 details
TNFL6_HUMANMOES_HUMANBioGRID15659383 details
TNFL6_HUMANRHOA_HUMANBioGRID15659383 details
TNFL6_HUMANGDIR1_HUMANBioGRID15659383 details
TNFL6_HUMANTNR1A_HUMANBioGRID12753742 15659383 details
TNFL6_HUMANCFLAR_HUMANBioGRID21803845 details
TNFL6_HUMANKMT2A_HUMANHPRD12023017 details
TNFL6_HUMANDMD_HUMANHPRD11741599 details
TNFL6_HUMANAPBB1_HUMANHPRD11741599 details
TNFL6_HUMANPR40A_HUMANHPRD11741599 details
TNFL6_HUMANPIN1_HUMANHPRD11741599 details