Entity Details

Primary name GSH0_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48507
EntryNameGSH0_HUMAN
FullNameGlutamate--cysteine ligase regulatory subunit
TaxID9606
Evidenceevidence at protein level
Length274
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesGCLM

GO terms

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GOName
GO:0004357 glutamate-cysteine ligase activity
GO:0005829 cytosol
GO:0006534 cysteine metabolic process
GO:0006536 glutamate metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006979 response to oxidative stress
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008637 apoptotic mitochondrial changes
GO:0014823 response to activity
GO:0017109 glutamate-cysteine ligase complex
GO:0030234 enzyme regulator activity
GO:0035226 glutamate-cysteine ligase catalytic subunit binding
GO:0035229 positive regulation of glutamate-cysteine ligase activity
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035733 hepatic stellate cell activation
GO:0042493 response to drug
GO:0043524 negative regulation of neuron apoptotic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044752 response to human chorionic gonadotropin
GO:0044877 protein-containing complex binding
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0051409 response to nitrosative stress
GO:0051900 regulation of mitochondrial depolarization
GO:0071333 cellular response to glucose stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0097069 cellular response to thyroxine stimulus
GO:0097746 blood vessel diameter maintenance
GO:1990830 cellular response to leukemia inhibitory factor
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR032963 Glutamate--cysteine ligase regulatory subunitFamilyFamily
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule