Entity Details

Primary name T23O_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48775
EntryNameT23O_HUMAN
FullNameTryptophan 2,3-dioxygenase
TaxID9606
Evidenceevidence at protein level
Length406
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesTDO2

GO terms

Show/Hide Table
GOName
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0005829 cytosol
GO:0006569 tryptophan catabolic process
GO:0016597 amino acid binding
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019442 tryptophan catabolic process to acetyl-CoA
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051289 protein homotetramerization
GO:1904842 response to nitroglycerin

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR004981 Tryptophan 2,3-dioxygenaseFamilyFamily
IPR037217 Tryptophan/Indoleamine 2,3-dioxygenase-likeFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
600627 OMIMHypertryptophanemia (HYPTRP)An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00150 TryptophanDrugbanksmall molecule
DB00500 TolmetinDrugbanksmall molecule
DB00779 Nalidixic acidSwissprotsmall molecule

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
T23O_HUMANASML_HUMANBioGRID, HPRD, IntAct16189514 24722188 25416956 28514442 32296183 details
T23O_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
T23O_HUMANANM6_HUMANBioGRID, MINT23455924 details
T23O_HUMANSDCB1_HUMANBioGRID, IntAct24722188 25416956 32296183 details
T23O_HUMANDPM1_HUMANBioGRID, IntAct25416956 25910212 details
T23O_HUMANIF4E_HUMANBioGRID, IntAct24722188 25416956 details
T23O_HUMANPSA1_HUMANBioGRID, IntAct25416956 details
T23O_HUMANMOB3C_HUMANBioGRID, IntAct25416956 details
T23O_HUMANZFY26_HUMANBioGRID, IntAct25416956 32296183 details
T23O_HUMANSDCB2_HUMANBioGRID, IntAct25416956 31515488 details
T23O_HUMANMOB1A_HUMANBioGRID, IntAct25416956 32296183 details
T23O_HUMANNGB_HUMANBioGRID, IntAct25416956 32296183 details
T23O_HUMANT23O_HUMANBioGRID, IntAct24722188 25416956 32296183 details
T23O_HUMANREL_HUMANBioGRID, IntAct24722188 details
T23O_HUMANNMNA1_HUMANBioGRID, IntAct24722188 32296183 details
T23O_HUMANP20D2_HUMANBioGRID, IntAct32296183 details
T23O_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
T23O_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
T23O_HUMANNR1D1_HUMANBioGRID, IntAct32296183 details
T23O_HUMANCALR_HUMANIntAct32814053 details
T23O_HUMANCADH1_HUMANIntAct32814053 details
T23O_HUMANODO2_HUMANIntAct32814053 details
T23O_HUMANSAHH2_HUMANIntAct32814053 details
T23O_HUMANNEK7_HUMANIntAct32814053 details
T23O_HUMANMEOX2_HUMANBioGRID24722188 details
T23O_HUMANLMNA_HUMANBioGRID24623722 details