Entity Details

Primary name FAS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49327
EntryNameFAS_HUMAN
FullNameFatty acid synthase
TaxID9606
Evidenceevidence at protein level
Length2511
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesFASN

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0002068 glandular epithelial cell development
GO:0003723 RNA binding
GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006084 acetyl-CoA metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008611 ether lipid biosynthetic process
GO:0008659 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
GO:0008693 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
GO:0016020 membrane
GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0019216 regulation of lipid metabolic process
GO:0030223 neutrophil differentiation
GO:0030224 monocyte differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0030879 mammary gland development
GO:0031177 phosphopantetheine binding
GO:0031325 positive regulation of cellular metabolic process
GO:0042470 melanosome
GO:0042587 glycogen granule
GO:0042802 identical protein binding
GO:0045296 cadherin binding
GO:0046949 fatty-acyl-CoA biosynthetic process
GO:0047117 enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0070062 extracellular exosome
GO:0071353 cellular response to interleukin-4
GO:0090557 establishment of endothelial intestinal barrier
GO:0102131 3-oxo-glutaryl-[acp] methyl ester reductase activity
GO:0102132 3-oxo-pimeloyl-[acp] methyl ester reductase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Melanosome

Domains

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DomainNameCategoryType
IPR001031 ThioesteraseDomainDomain
IPR001227 Acyl transferase domain superfamilyFamilyHomologous superfamily
IPR006162 Phosphopantetheine attachment sitePTMPTM
IPR009081 Phosphopantetheine binding ACP domainDomainDomain
IPR011032 GroES-like superfamilyFamilyHomologous superfamily
IPR013149 Alcohol dehydrogenase, C-terminalDomainDomain
IPR013217 Methyltransferase type 12DomainDomain
IPR013968 Polyketide synthase, ketoreductase domainDomainDomain
IPR014030 Beta-ketoacyl synthase, N-terminalDomainDomain
IPR014031 Beta-ketoacyl synthase, C-terminalDomainDomain
IPR014043 Acyl transferaseDomainDomain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipaseFamilyHomologous superfamily
IPR016036 Malonyl-CoA ACP transacylase, ACP-bindingFamilyHomologous superfamily
IPR016039 Thiolase-likeFamilyHomologous superfamily
IPR018201 Beta-ketoacyl synthase, active siteSiteActive site
IPR020806 Polyketide synthase, phosphopantetheine-binding domainDomainDomain
IPR020807 Polyketide synthase, dehydratase domainDomainDomain
IPR020841 Polyketide synthase, beta-ketoacyl synthase domainDomainDomain
IPR020843 Polyketide synthase, enoylreductase domainDomainDomain
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR032821 Polyketide synthase, C-terminal extensionDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR036736 ACP-like superfamilyFamilyHomologous superfamily
IPR042104 Polyketide synthase, dehydratase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01034 CeruleninDrugbanksmall molecule
DB01083 OrlistatDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
FAS_HUMANEWS_HUMANBioGRID, HPRD, IntAct16189514 details
FAS_HUMANPRR12_HUMANBioGRID, IntAct21988832 details
FAS_HUMANHS90A_HUMANBioGRID, IntAct16263121 21360678 31273033 31536960 details
FAS_HUMANAKT1_HUMANBioGRID, IntAct, MINT25640309 31980649 details
FAS_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
FAS_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
FAS_HUMANADIPO_HUMANBioGRID, IntAct32296183 details
FAS_HUMANHD_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
FAS_HUMANFAS_HUMANBioGRID, HPRD11248039 details
FAS_HUMANUBP2_HUMANBioGRID15050917 22370483 details
FAS_HUMAN1433T_HUMANBioGRID15161933 details
FAS_HUMANPTEN_HUMANBioGRID26561776 details
FAS_HUMANSUMO2_HUMANBioGRID32786267 details
FAS_HUMANNEMO_HUMANIntAct14743216 details
FAS_HUMANM3K1_HUMANIntAct14743216 details
FAS_HUMANM3K3_HUMANIntAct14743216 details
FAS_HUMANNFKB2_HUMANIntAct14743216 details
FAS_HUMAN1433Z_HUMANMINT15161933 details
FAS_HUMANLACC1_HUMANIntAct27478939 details
FAS_HUMANHDAC5_HUMANBioGRID21081666 details
FAS_HUMANMK03_HUMANBioGRID19847302 details
FAS_HUMANTS101_HUMANBioGRID19542561 details
FAS_HUMANISG15_HUMANBioGRID16009940 33024031 details
FAS_HUMANPTN11_HUMANBioGRID23269672 details
FAS_HUMANVHL_HUMANBioGRID28775317 details
FAS_HUMANPYR1_HUMANBioGRID28775317 details
FAS_HUMANHIF1A_HUMANBioGRID27320910 28775317 details
FAS_HUMANFGF11_HUMANBioGRID28027390 details
FAS_HUMANCAV1_HUMANBioGRID18635971 details
FAS_HUMANSPOP_HUMANBioGRID30955223 details