Entity Details

Primary name PO3F4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49335
EntryNamePO3F4_HUMAN
FullNamePOU domain, class 3, transcription factor 4
TaxID9606
Evidenceevidence at protein level
Length361
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesPOU3F4

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007420 brain development
GO:0007605 sensory perception of sound
GO:0090103 cochlea morphogenesis
GO:1990837 sequence-specific double-stranded DNA binding
GO:2001054 negative regulation of mesenchymal cell apoptotic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000327 POU-specific domainDomainDomain
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013847 POU domainDomainDomain
IPR016362 POU-domain transcription factor, class 3FamilyFamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
304400 OMIMDeafness, X-linked, 2 (DFNX2)A form of deafness characterized by both conductive hearing loss resulting from stapes (perilymphatic gusher) fixation, and progressive sensorineural deafness. The disease is caused by variants affecting the gene represented in this entry.