Entity Details

Primary name SYCC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49589
EntryNameSYCC_HUMAN
FullNameCysteine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length748
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesCARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0004817 cysteine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006423 cysteinyl-tRNA aminoacylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR015803 Cysteine-tRNA ligaseFamilyFamily
IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligaseFamilyFamily
IPR032678 tRNA synthetases class I, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
618891 OMIMMicrocephaly, developmental delay, and brittle hair syndrome (MDBH)An autosomal recessive disorder characterized by developmental delay, motor and cognitive disabilities, brittle hair and nails, failure to thrive, and short stature. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00151 CysteineDrugbanksmall molecule