Entity Details

Primary name CTCF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49711
EntryNameCTCF_HUMAN
FullNameTranscriptional repressor CTCF
TaxID9606
Evidenceevidence at protein level
Length727
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCTCF

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001221 transcription coregulator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006306 DNA methylation
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007059 chromosome segregation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0010216 maintenance of DNA methylation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016584 nucleosome positioning
GO:0031060 regulation of histone methylation
GO:0035065 regulation of histone acetylation
GO:0040029 regulation of gene expression, epigenetic
GO:0040030 regulation of molecular function, epigenetic
GO:0043035 chromatin insulator sequence binding
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071459 protein localization to chromosome, centromeric region
GO:0071514 genetic imprinting

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615502 OMIMMental retardation, autosomal dominant 21 (MRD21)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Additional MRD21 features include short stature, microcephaly, and developmental delay. The disease is caused by variants affecting the gene represented in this entry.

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
CTCF_HUMANHSPB9_HUMANIntAct15503857 details
CTCF_HUMANCHD8_HUMANBioGRID, IntAct16949368 details
CTCF_HUMANNU4M_HUMANBioGRID, MINT24725430 details
CTCF_HUMANRALA_HUMANBioGRID, MINT24725430 details
CTCF_HUMANRL31_HUMANBioGRID, MINT24725430 30459231 details
CTCF_HUMANDDX17_HUMANBioGRID, MINT24725430 30459231 details
CTCF_HUMANVIGLN_HUMANBioGRID, MINT24725430 31917284 details
CTCF_HUMANCHD1L_HUMANBioGRID, MINT24725430 details
CTCF_HUMANZMYM6_HUMANBioGRID, IntAct32296183 details
CTCF_HUMANZMYM4_HUMANBioGRID, IntAct25416956 details
CTCF_HUMANCHD7_HUMANBioGRID17603073 details
CTCF_HUMANTRAF2_HUMANBioGRID, IntAct32296183 details
CTCF_HUMANRHOU_HUMANBioGRID26598620 details
CTCF_HUMANRPB1_HUMANBioGRID, HPRD12054881 17210645 21880767 details
CTCF_HUMANA4_HUMANIntAct32814053 details
CTCF_HUMANPARP1_HUMANBioGRID14759373 19450526 20038529 details
CTCF_HUMANSUZ12_HUMANBioGRID18662993 21536749 details
CTCF_HUMANRAD51_HUMANBioGRID28973861 details
CTCF_HUMANSMAD3_HUMANBioGRID, HPRD12099698 20427289 details
CTCF_HUMANYBOX1_HUMANBioGRID, HPRD10906122 15229244 details
CTCF_HUMANSIN3A_HUMANBioGRID10734189 details
CTCF_HUMANRXRA_HUMANBioGRID20404925 details
CTCF_HUMANSMC1A_HUMANBioGRID, MINT18219272 details
CTCF_HUMANKDM5B_HUMANIntAct24937458 details
CTCF_HUMANNPM_HUMANBioGRID14759373 19450526 30459231 details
CTCF_HUMANRAD21_HUMANBioGRID, MINT18219272 details
CTCF_HUMANH2AZ_HUMANBioGRID14759373 details
CTCF_HUMANPO5F1_HUMANDIP19536159 details
CTCF_HUMANKAISO_HUMANBioGRID16230345 details
CTCF_HUMANLMNA_HUMANBioGRID14759373 details
CTCF_HUMANTOP2A_HUMANBioGRID14759373 details
CTCF_HUMANTYY1_HUMANBioGRID17218270 details
CTCF_HUMANNUCL_HUMANBioGRID19450526 details
CTCF_HUMANIMA1_HUMANBioGRID14759373 details
CTCF_HUMANHMGB1_HUMANHPRD11748221 details
CTCF_HUMANEZH2_HUMANBioGRID31917284 details
CTCF_HUMANH2A2C_HUMANBioGRID14759373 details
CTCF_HUMANIMA3_HUMANBioGRID14759373 details
CTCF_HUMANHIRA_HUMANBioGRID23602572 details
CTCF_HUMANSMC3_HUMANBioGRID21880767 details
CTCF_HUMANMDC1_HUMANBioGRID28973861 details
CTCF_HUMANTAF3_HUMANBioGRID21884934 details
CTCF_HUMANTOP2B_HUMANBioGRID19450526 details
CTCF_HUMANSET_HUMANBioGRID14759373 details
CTCF_HUMANAGO2_HUMANBioGRID28973861 details
CTCF_HUMANDDX5_HUMANBioGRID30459231 details
CTCF_HUMANSMCA4_HUMANBioGRID30459231 details
CTCF_HUMANTHB_HUMANHPRD10625678 details
CTCF_HUMANSMAD4_HUMANHPRD12099698 details