Entity Details

Primary name NUMB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49757
EntryNameNUMB_HUMAN
FullNameProtein numb homolog
TaxID9606
Evidenceevidence at protein level
Length651
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNUMB

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0005925 focal adhesion
GO:0007409 axonogenesis
GO:0008013 beta-catenin binding
GO:0010008 endosome membrane
GO:0016323 basolateral plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0021670 lateral ventricle development
GO:0021849 neuroblast division in subventricular zone
GO:0030136 clathrin-coated vesicle
GO:0030335 positive regulation of cell migration
GO:0034332 adherens junction organization
GO:0045177 apical part of cell
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0050769 positive regulation of neurogenesis
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1903077 negative regulation of protein localization to plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR006020 PTB/PI domainDomainDomain
IPR010449 NUMB domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016698 Numb/numb-likeFamilyFamily

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
NUMB_HUMANEPS15_HUMANBioGRID, HPRD, IntAct, MINT10953014 23211419 9303539 details
NUMB_HUMANEGFR_HUMANBioGRID, MINT16273093 25754235 details
NUMB_HUMANLNX1_HUMANBioGRID, HPRD, IntAct11782429 14990566 16002321 29121065 9535908 details
NUMB_HUMANKPCZ_HUMANBioGRID, HPRD, MINT17203073 details
NUMB_HUMANAP2A1_HUMANBioGRID, HPRD, IntAct, MINT12942088 17203073 23211419 details
NUMB_HUMANRL3_HUMANBioGRID, IntAct21988832 details
NUMB_HUMANSIAH1_HUMANBioGRID, HPRD, IntAct11752454 21988832 details
NUMB_HUMANA4_HUMANBioGRID, HPRD, IntAct12011466 21832049 25241761 32814053 details
NUMB_HUMANOLIG1_HUMANBioGRID, IntAct25814554 details
NUMB_HUMANIRS1_HUMANBioGRID, IntAct25814554 details
NUMB_HUMANFRS3_HUMANBioGRID, IntAct25814554 details
NUMB_HUMANTERF2_HUMANBioGRID, IntAct25814554 details
NUMB_HUMANLNX2_HUMANBioGRID, HPRD, IntAct11782429 11922143 25814554 26451611 details
NUMB_HUMANJIP2_HUMANBioGRID, IntAct25814554 details
NUMB_HUMANMDM2_HUMANBioGRID, DIP, HPRD12646252 16678796 18172499 22337874 23252402 27106262 28223335 29269425 31451549 31533005 9632782 details
NUMB_HUMANP53_HUMANBioGRID, DIP18172499 22157679 23881403 27106262 28223335 29269425 details
NUMB_HUMANDNJC5_HUMANBioGRID, IntAct29997244 33957083 details
NUMB_HUMANDPYL2_HUMANBioGRID, HPRD11121447 12942088 details
NUMB_HUMANITCH_HUMANBioGRID, HPRD12682059 18628966 20818436 details
NUMB_HUMANNOTC1_HUMANBioGRID, HPRD12682059 23252402 8755477 details
NUMB_HUMANGLI1_HUMANBioGRID20818436 details
NUMB_HUMANKPCA_HUMANBioGRID, HPRD17203073 details
NUMB_HUMANKPCE_HUMANBioGRID, HPRD17203073 details
NUMB_HUMANKPCB_HUMANBioGRID, HPRD17203073 details
NUMB_HUMANFBX7_HUMANBioGRID27503909 details
NUMB_HUMANNEDD4_HUMANBioGRID28437168 details
NUMB_HUMANPTEN_HUMANBioGRID28437168 details
NUMB_HUMANPALS1_HUMANBioGRID32296183 details
NUMB_HUMANEAF1_HUMANBioGRID32296183 details
NUMB_HUMANPDZ1I_HUMANBioGRID32296183 details
NUMB_HUMANSPXN2_HUMANBioGRID32296183 details
NUMB_HUMANAP2A2_HUMANHPRD, IntAct17203073 23211419 details
NUMB_HUMANRBP1_HUMANBioGRID, IntAct12775724 23211419 details
NUMB_HUMANREPS1_HUMANIntAct23211419 details
NUMB_HUMANDCAF7_HUMANBioGRID, IntAct27173435 unassigned1312 details
NUMB_HUMANTULP3_HUMANBioGRID, IntAct28514442 33187986 details
NUMB_HUMANCTNB1_HUMANDIP24561623 details
NUMB_HUMANL1CAM_HUMANBioGRID, HPRD12942088 details
NUMB_HUMANSHOT1_HUMANBioGRID28981589 details
NUMB_HUMANRASH_HUMANBioGRID30442766 30639242 details
NUMB_HUMANTRPV6_HUMANBioGRID23140583 details
NUMB_HUMANSMAP2_HUMANBioGRID29395067 details
NUMB_HUMANITB3_HUMANHPRD12606711 details
NUMB_HUMANITB2_HUMANHPRD12606711 details
NUMB_HUMANKPCG_HUMANHPRD17203073 details
NUMB_HUMANKPCD_HUMANHPRD17203073 details
NUMB_HUMANKPCL_HUMANHPRD17203073 details
NUMB_HUMANITB5_HUMANHPRD12606711 details