Entity Details

Primary name RBP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49792
EntryNameRBP2_HUMAN
FullNameE3 SUMO-protein ligase RanBP2
TaxID9606
Evidenceevidence at protein level
Length3224
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesRANBP2

GO terms

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GOName
GO:0000413 protein peptidyl-prolyl isomerization
GO:0001975 response to amphetamine
GO:0003723 RNA binding
GO:0005635 nuclear envelope
GO:0005642 annulate lamellae
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006110 regulation of glycolytic process
GO:0006111 regulation of gluconeogenesis
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006457 protein folding
GO:0006607 NLS-bearing protein import into nucleus
GO:0007052 mitotic spindle organization
GO:0016020 membrane
GO:0016032 viral process
GO:0016925 protein sumoylation
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0019789 SUMO transferase activity
GO:0031267 small GTPase binding
GO:0031965 nuclear membrane
GO:0033133 positive regulation of glucokinase activity
GO:0042405 nuclear inclusion body
GO:0043231 intracellular membrane-bounded organelle
GO:0043547 positive regulation of GTPase activity
GO:0043657 host cell
GO:0044614 nuclear pore cytoplasmic filaments
GO:0044615 nuclear pore nuclear basket
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0051642 centrosome localization
GO:0060964 regulation of gene silencing by miRNA
GO:0075733 intracellular transport of virus
GO:1900034 regulation of cellular response to heat
GO:1990723 cytoplasmic periphery of the nuclear pore complex

Subcellular Location

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Subcellular Location
Nucleus
Nucleus envelope
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000156 Ran binding domainDomainDomain
IPR001876 Zinc finger, RanBP2-typeDomainDomain
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved siteSiteConserved site
IPR022011 Nup358/RanBP2 E3 ligase domainDomainDomain
IPR029000 Cyclophilin-like domain superfamilyFamilyHomologous superfamily
IPR036443 Zinc finger, RanBP2-type superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608033 OMIMEncephalopathy, acute, infection-induced, 3 (IIAE3)A rapidly progressive encephalopathy manifesting in susceptible individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem. The disease is caused by variants affecting the gene represented in this entry. Mutations in the RANBP2 gene predispose to IIAE3, but by themselves are insufficient to make the phenotype fully penetrant; additional genetic and environmental factors are required (PubMed:19118815).

Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
RBP2_HUMANPRKN_HUMANBioGRID, HPRD, IntAct16332688 details
RBP2_HUMANUBC9_HUMANBioGRID, HPRD, IntAct11709548 11792325 12192048 15608651 15931224 17353931 19785004 20936779 22194619 22464730 26261240 26496610 28514442 details
RBP2_HUMANAPC_HUMANBioGRID, IntAct19654215 20936779 29045831 details
RBP2_HUMANAKP13_HUMANBioGRID, IntAct20936779 details
RBP2_HUMANARI4B_HUMANBioGRID, IntAct20936779 details
RBP2_HUMANFHOD1_HUMANBioGRID, IntAct20936779 details
RBP2_HUMANAMRP_HUMANBioGRID, IntAct20936779 details
RBP2_HUMANTAF1_HUMANBioGRID, IntAct20936779 details
RBP2_HUMANIF140_HUMANBioGRID, IntAct20936779 details
RBP2_HUMANRBP2_HUMANBioGRID, IntAct16194093 20936779 details
RBP2_HUMANIMA1_HUMANBioGRID, IntAct21988832 details
RBP2_HUMANCUL1_HUMANBioGRID, IntAct21988832 details
RBP2_HUMANRAN_HUMANBioGRID, DIP, HPRD, IntAct10078529 10318915 11470507 20547757 21988832 24855949 26344197 28514442 7603572 details
RBP2_HUMANMYPC2_HUMANBioGRID, IntAct23414517 details
RBP2_HUMANPDLI3_HUMANBioGRID, IntAct23414517 details
RBP2_HUMANNXF1_HUMANBioGRID, UniProt10668806 16314397 18596238 20123736 26344197 details
RBP2_HUMANIMB1_HUMANBioGRID, HPRD, IntAct10473610 11266456 12894213 26496610 8909533 9398662 details
RBP2_HUMANRAGP1_HUMANBioGRID, HPRD, IntAct11709548 11854305 12192048 16204249 21518904 22194619 22464730 26344197 9019411 details
RBP2_HUMANIMA5_HUMANBioGRID10473610 details
RBP2_HUMANBOREA_HUMANBioGRID18946085 details
RBP2_HUMANHDAC4_HUMANBioGRID, HPRD12032081 27684187 31040226 details
RBP2_HUMANCALM1_HUMANBioGRID15840729 details
RBP2_HUMANCALM2_HUMANBioGRID15840729 details
RBP2_HUMANCALM3_HUMANBioGRID15840729 details
RBP2_HUMANSENP1_HUMANBioGRID22194619 details
RBP2_HUMANP53_HUMANBioGRID22194619 29379164 details
RBP2_HUMANTOP2B_HUMANBioGRID18394993 details
RBP2_HUMANSP100_HUMANBioGRID11792325 15608651 details
RBP2_HUMANSUMO1_HUMANBioGRID16524884 18359863 19785004 22578841 details
RBP2_HUMANSUMO2_HUMANBioGRID16524884 32786267 details
RBP2_HUMANUBTD1_HUMANBioGRID24211586 details
RBP2_HUMANNUP62_HUMANBioGRID, HPRD11266456 16730000 details
RBP2_HUMANWASP_HUMANBioGRID26261240 details
RBP2_HUMANMDM2_HUMANBioGRID, HPRD12393906 29295817 details
RBP2_HUMANMP2K7_HUMANBioGRID26364603 details
RBP2_HUMANPTEN_HUMANBioGRID31685992 details
RBP2_HUMANNFX1_HUMANBioGRID31375530 details
RBP2_HUMANTOP2A_HUMANBioGRID, IntAct18394993 26344197 details
RBP2_HUMANKINH_HUMANBioGRID, MINT17887960 19305391 details
RBP2_HUMANERBB2_HUMANUniProt16314522 details
RBP2_HUMANNU153_HUMANBioGRID, IntAct26496610 7603572 details
RBP2_HUMANBICD2_HUMANBioGRID, DIP20386726 28718761 details
RBP2_HUMANBIN1_HUMANIntAct31413325 details
RBP2_HUMANCDC73_HUMANBioGRID15632063 details
RBP2_HUMANAIRE_HUMANBioGRID20085707 details
RBP2_HUMANPSMD1_HUMANBioGRID9733766 details
RBP2_HUMANRPGF3_HUMANBioGRID20547757 21670213 details
RBP2_HUMANKIFA3_HUMANBioGRID19654215 details
RBP2_HUMANKIF3A_HUMANBioGRID19654215 details
RBP2_HUMANKIF5C_HUMANBioGRID17887960 details
RBP2_HUMANNU214_HUMANBioGRID7603572 details
RBP2_HUMANPML_HUMANBioGRID22155184 details
RBP2_HUMANIPO5_HUMANBioGRID, HPRD26344197 9114010 details
RBP2_HUMANKIF3B_HUMANBioGRID9733766 details
RBP2_HUMANANM5_HUMANBioGRID26658161 details
RBP2_HUMANUBC12_HUMANBioGRID26364603 details
RBP2_HUMANPCNA_HUMANBioGRID32900933 details
RBP2_HUMANOPSG_HUMANHPRD8857542 details
RBP2_HUMANOPSG2_HUMANHPRD8857542 details
RBP2_HUMANOPSG3_HUMANHPRD8857542 details
RBP2_HUMANXPO1_HUMANHPRD10601307 details
RBP2_HUMANTNPO1_HUMANHPRD9144189 details
RBP2_HUMANXPOT_HUMANHPRD12138183 details