Entity Details

Primary name CDK7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50613
EntryNameCDK7_HUMAN
FullNameCyclin-dependent kinase 7
TaxID9606
Evidenceevidence at protein level
Length346
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCDK7

GO terms

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GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000439 transcription factor TFIIH core complex
GO:0001650 fibrillar center
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005675 transcription factor TFIIH holo complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006468 protein phosphorylation
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0042795 snRNA transcription by RNA polymerase II
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048471 perinuclear region of cytoplasm
GO:0050821 protein stabilization
GO:0051301 cell division
GO:0070516 CAK-ERCC2 complex
GO:0070816 phosphorylation of RNA polymerase II C-terminal domain
GO:0070985 transcription factor TFIIK complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR037770 Cyclin-dependent kinase 7FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02482 PhosphonothreonineDrugbanksmall molecule
DB03496 AlvocidibDrugbanksmall molecule
DB05969 SNS-032Drugbanksmall molecule
DB06195 SeliciclibDrugbanksmall molecule

Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
CDK7_HUMANMAT1_HUMANBioGRID, HPRD, IntAct10082552 10801852 12527756 17643375 22939629 23602568 26186194 26340423 26344197 28514442 29568061 8521393 8521818 9130708 9334327 details
CDK7_HUMANCCNH_HUMANBioGRID, HPRD, IntAct10082552 10958691 11113184 11713533 15328539 15698475 16782892 17643375 22939629 23602568 26186194 26340423 26344197 28514442 29568061 8078587 8521393 8521818 8692841 9056480 9218599 9334327 details
CDK7_HUMANDHB4_HUMANBioGRID, IntAct21988832 details
CDK7_HUMANDQA1_HUMANBioGRID, IntAct21988832 details
CDK7_HUMANCDK2_HUMANBioGRID, DIP, HPRD, IntAct10393546 11113184 15282296 15530371 16191191 16327805 23064645 23455922 25852190 7629134 8647086 8692842 details
CDK7_HUMANTF2H1_HUMANBioGRID, HPRD, IntAct23602568 26340423 28977422 29568061 7533895 8521393 8692841 9130708 9852112 details
CDK7_HUMANERCC3_HUMANBioGRID, HPRD, IntAct10082552 15220921 17643375 23602568 26340423 28514442 28977422 29568061 8521393 8692841 9130708 details
CDK7_HUMANTF2H2_HUMANBioGRID, HPRD, IntAct11062469 17643375 19934020 23602568 28977422 29568061 9130708 details
CDK7_HUMANTF2H3_HUMANBioGRID, IntAct17643375 21157430 23602568 28977422 29568061 details
CDK7_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
CDK7_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
CDK7_HUMANCCNB1_HUMANBioGRID, IntAct11113184 26186194 28514442 details
CDK7_HUMANCCNA2_HUMANBioGRID, IntAct11113184 16327805 26186194 28514442 details
CDK7_HUMANCDK1_HUMANBioGRID, DIP, HPRD11113184 16327805 7944411 details
CDK7_HUMANRPB1_HUMANBioGRID, DIP11278802 15009212 15282296 15328539 15530371 16327805 18391197 20106982 22379099 23064645 32355176 8692842 9311822 details
CDK7_HUMANCDK4_HUMANDIP16327805 details
CDK7_HUMANCDK19_HUMANDIP16327805 details
CDK7_HUMANSPT5H_HUMANBioGRID, DIP10958691 16327805 details
CDK7_HUMANCD11B_HUMANBioGRID, DIP, IntAct16327805 29568061 details
CDK7_HUMANCDC37_HUMANBioGRID, IntAct26186194 29568061 8666233 details
CDK7_HUMANT2EA_HUMANBioGRID, IntAct15282296 23064645 25492609 29568061 details
CDK7_HUMANT2EB_HUMANBioGRID, IntAct23064645 29568061 details
CDK7_HUMANH11_HUMANBioGRID, IntAct30021884 8692842 details
CDK7_HUMANESR1_HUMANBioGRID, HPRD, IntAct10949034 15461668 31527615 details
CDK7_HUMANANDR_HUMANBioGRID, HPRD10734072 21157430 details
CDK7_HUMANCUX1_HUMANBioGRID11584018 details
CDK7_HUMANCASP_HUMANBioGRID11584018 details
CDK7_HUMANTCEA1_HUMANBioGRID26186194 9305922 details
CDK7_HUMANP53_HUMANBioGRID9315650 9372954 9840937 details
CDK7_HUMANTHA_HUMANBioGRID, HPRD15249124 details
CDK7_HUMANTAF7_HUMANBioGRID18391197 details
CDK7_HUMANCDK9_HUMANBioGRID11145967 23064645 9184228 details
CDK7_HUMANSMAD1_HUMANBioGRID19914168 details
CDK7_HUMANCTDP1_HUMANBioGRID19914168 details
CDK7_HUMANKPCI_HUMANBioGRID21315177 details
CDK7_HUMANRPB2_HUMANBioGRID9334327 details
CDK7_HUMANCDK6_HUMANBioGRID7629134 details
CDK7_HUMANCDK7_HUMANBioGRID, HPRD10082552 10993082 11113184 23602568 29568061 9056480 9315650 details
CDK7_HUMANUB2D1_HUMANBioGRID21157430 details
CDK7_HUMANA4_HUMANBioGRID21832049 details
CDK7_HUMANMBP_HUMANBioGRID15328539 details
CDK7_HUMANCCND2_HUMANBioGRID17873913 details
CDK7_HUMANRARA_HUMANHPRD15249124 details
CDK7_HUMANVDR_HUMANHPRD15249124 details
CDK7_HUMANERCC2_HUMANBioGRID, HPRD, IntAct11445587 22939629 23602568 26186194 28514442 29568061 8692841 details
CDK7_HUMANTF2H5_HUMANBioGRID, HPRD, IntAct15220921 23602568 26496610 29568061 details
CDK7_HUMANHS90B_HUMANBioGRID, IntAct17643375 22939624 26186194 28514442 details
CDK7_HUMANE2F1_HUMANBioGRID, HPRD, IntAct10428966 20106982 23397142 details
CDK7_HUMANHS90A_HUMANBioGRID, IntAct22939624 26186194 28514442 details
CDK7_HUMANPCGF6_HUMANBioGRID, HPRD, IntAct12167161 29568061 details
CDK7_HUMANMTA1_HUMANBioGRID12527756 details
CDK7_HUMANHDAC2_HUMANBioGRID12527756 details
CDK7_HUMANMED21_HUMANBioGRID9315662 details
CDK7_HUMANMCM7_HUMANBioGRID, HPRD11056214 details
CDK7_HUMANHNRPU_HUMANBioGRID10490622 17643375 details
CDK7_HUMANANXA2_HUMANBioGRID8692841 details
CDK7_HUMANBRCA1_HUMANBioGRID, HPRD15282296 details
CDK7_HUMANUVSSA_HUMANBioGRID22902626 details
CDK7_HUMANUBC_HUMANBioGRID28190767 details
CDK7_HUMANCDN1C_HUMANBioGRID20106982 details
CDK7_HUMANNEK6_HUMANHPRD12023960 details
CDK7_HUMANLASP1_HUMANHPRD12571245 details