Entity Details

Primary name AT1A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50993
EntryNameAT1A2_HUMAN
FullNameSodium/potassium-transporting ATPase subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length1020
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesATP1A2

GO terms

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GOName
GO:0001504 neurotransmitter uptake
GO:0001662 behavioral fear response
GO:0002026 regulation of the force of heart contraction
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005496 steroid binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0005901 caveola
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 cellular sodium ion homeostasis
GO:0006937 regulation of muscle contraction
GO:0006940 regulation of smooth muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0008217 regulation of blood pressure
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010996 response to auditory stimulus
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016791 phosphatase activity
GO:0016887 ATP hydrolysis activity
GO:0019229 regulation of vasoconstriction
GO:0019829 ATPase-coupled cation transmembrane transporter activity
GO:0021764 amygdala development
GO:0021989 olfactory cortex development
GO:0030007 cellular potassium ion homeostasis
GO:0030315 T-tubule
GO:0030955 potassium ion binding
GO:0031090 organelle membrane
GO:0031402 sodium ion binding
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0035641 locomotory exploration behavior
GO:0035725 sodium ion transmembrane transport
GO:0036376 sodium ion export across plasma membrane
GO:0040011 locomotion
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0045822 negative regulation of heart contraction
GO:0045823 positive regulation of heart contraction
GO:0045988 negative regulation of striated muscle contraction
GO:0046034 ATP metabolic process
GO:0046982 protein heterodimerization activity
GO:0051087 chaperone binding
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0055119 relaxation of cardiac muscle
GO:0060048 cardiac muscle contraction
GO:0071260 cellular response to mechanical stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:0071805 potassium ion transmembrane transport
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086009 membrane repolarization
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0098655 cation transmembrane transport
GO:0150104 transport across blood-brain barrier
GO:1902600 proton transmembrane transport
GO:1903170 negative regulation of calcium ion transmembrane transport
GO:1903280 negative regulation of calcium:sodium antiporter activity
GO:1903416 response to glycoside
GO:1903561 extracellular vesicle
GO:1903779 regulation of cardiac conduction
GO:1990239 steroid hormone binding
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR005775 P-type ATPase subfamily IIC, subunit alphaFamilyFamily
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Disease IDSourceNameDescription
602481 OMIMMigraine, familial hemiplegic, 2 (FHM2)A subtype of migraine with aura associated with hemiparesis in some families. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. The disease is caused by variants affecting the gene represented in this entry.
104290 OMIMAlternating hemiplegia of childhood 1 (AHC1)A rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01092 OuabainDrugbanksmall molecule
DB09479 Rubidium Rb-82Swissprotsmall molecule

Interactions

4 interactions