Entity Details

Primary name RAB7A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51149
EntryNameRAB7A_HUMAN
FullNameRas-related protein Rab-7a
TaxID9606
Evidenceevidence at protein level
Length207
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesRAB7A

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000421 autophagosome membrane
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006622 protein targeting to lysosome
GO:0006897 endocytosis
GO:0007174 epidermal growth factor catabolic process
GO:0008333 endosome to lysosome transport
GO:0010008 endosome membrane
GO:0015031 protein transport
GO:0016042 lipid catabolic process
GO:0019003 GDP binding
GO:0019076 viral release from host cell
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022615 protein to membrane docking
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0032419 extrinsic component of lysosome membrane
GO:0033162 melanosome membrane
GO:0034054 suppression by symbiont of host defense-related programmed cell death
GO:0042147 retrograde transport, endosome to Golgi
GO:0043312 neutrophil degranulation
GO:0045022 early endosome to late endosome transport
GO:0045335 phagocytic vesicle
GO:0045732 positive regulation of protein catabolic process
GO:0048524 positive regulation of viral process
GO:0061724 lipophagy
GO:0070062 extracellular exosome
GO:0090382 phagosome maturation
GO:0090383 phagosome acidification
GO:0090385 phagosome-lysosome fusion
GO:0099638 endosome to plasma membrane protein transport
GO:1902586 multi-organism intercellular transport
GO:1903542 negative regulation of exosomal secretion
GO:1903543 positive regulation of exosomal secretion
GO:1905366 negative regulation of intralumenal vesicle formation
GO:1905394 retromer complex binding

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Endosome membrane
Late endosome membrane
Lipid droplet
Lysosome membrane
Melanosome membrane

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
600882 OMIMCharcot-Marie-Tooth disease 2B (CMT2B)A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule

Interactions

91 interactions

InteractorPartnerSourcesPublicationsLink
RAB7A_HUMANRILP_HUMANBioGRID, DIP, HPRD, IntAct, UniProt11179213 11448994 15933719 18552835 18787122 25080504 25445562 25533187 25908847 26496610 26911690 30721249 32814053 details
RAB7A_HUMANPCNA_HUMANUniProt26030842 details
RAB7A_HUMANOSBL1_HUMANUniProt30721249 details
RAB7A_HUMANCL074_HUMANIntAct32814053 details
RAB7A_HUMANWDR61_HUMANIntAct32814053 details
RAB7A_HUMANATLA1_HUMANIntAct32814053 details
RAB7A_HUMANCHIP_HUMANIntAct32814053 details
RAB7A_HUMANCSN3_HUMANIntAct32814053 details
RAB7A_HUMANID3_HUMANIntAct32814053 details
RAB7A_HUMANRAE1_HUMANBioGRID, HPRD12576024 9563513 details
RAB7A_HUMANRAB17_HUMANBioGRID10329441 details
RAB7A_HUMANRAB4A_HUMANBioGRID10329441 34079125 details
RAB7A_HUMANRAB4B_HUMANBioGRID10329441 details
RAB7A_HUMANRAB5A_HUMANBioGRID10329441 22939629 26344197 34079125 details
RAB7A_HUMANRAB5B_HUMANBioGRID10329441 26344197 details
RAB7A_HUMANRAB6A_HUMANBioGRID10329441 details
RAB7A_HUMANRB22A_HUMANBioGRID10329441 details
RAB7A_HUMANUCHL5_HUMANBioGRID21800051 details
RAB7A_HUMANRN115_HUMANBioGRID, HPRD12972561 details
RAB7A_HUMANKR109_HUMANBioGRID25416956 details
RAB7A_HUMANKR103_HUMANBioGRID25416956 details
RAB7A_HUMANSNX3_HUMANBioGRID24344282 details
RAB7A_HUMANVP26A_HUMANBioGRID24344282 details
RAB7A_HUMANVPS35_HUMANBioGRID24344282 29893854 details
RAB7A_HUMANVPS29_HUMANBioGRID24344282 details
RAB7A_HUMANVPS11_HUMANBioGRID25445562 details
RAB7A_HUMANVPS16_HUMANBioGRID25445562 details
RAB7A_HUMANVPS18_HUMANBioGRID25445562 details
RAB7A_HUMANVPS39_HUMANBioGRID25445562 details
RAB7A_HUMANVPS41_HUMANBioGRID25445562 details
RAB7A_HUMANPRKN_HUMANBioGRID26911690 details
RAB7A_HUMANP53_HUMANBioGRID27229929 details
RAB7A_HUMANPRAF1_HUMANBioGRID, HPRD10329441 29360040 details
RAB7A_HUMANRAB13_HUMANBioGRID21795389 details
RAB7A_HUMANVHL_HUMANIntAct17353931 details
RAB7A_HUMANCRCM_HUMANIntAct17353931 details
RAB7A_HUMANATG5_HUMANIntAct17353931 details
RAB7A_HUMANGBRL2_HUMANIntAct17353931 details
RAB7A_HUMAN3MG_HUMANIntAct17353931 details
RAB7A_HUMANIKKE_HUMANIntAct17353931 details
RAB7A_HUMANTRAF6_HUMANIntAct17353931 details
RAB7A_HUMANAAKB1_HUMANIntAct17353931 details
RAB7A_HUMANHLAB_HUMANIntAct17353931 details
RAB7A_HUMANSH3K1_HUMANMINT20711168 details
RAB7A_HUMANDYN2_HUMANMINT20711168 details
RAB7A_HUMANATG9A_HUMANMINT21169990 details
RAB7A_HUMANGDIA_HUMANBioGRID, IntAct26496610 28514442 29360040 details
RAB7A_HUMANVDAC2_HUMANBioGRID, IntAct26496610 29360040 31536960 details
RAB7A_HUMANZFY27_HUMANDIP25855459 details
RAB7A_HUMANPKHM1_HUMANBioGRID, IntAct27291868 27777970 details
RAB7A_HUMANRHEB_HUMANBioGRID15809346 26344197 details
RAB7A_HUMANPSA7_HUMANBioGRID14998988 details
RAB7A_HUMANLST2_HUMANBioGRID19460345 details
RAB7A_HUMANGLUT4_HUMANBioGRID, HPRD16396496 details
RAB7A_HUMANKCNN4_HUMANBioGRID20720181 details
RAB7A_HUMANAT132_HUMANBioGRID22768177 details
RAB7A_HUMANLEG3_HUMANBioGRID24619419 details
RAB7A_HUMANARL8B_HUMANBioGRID26344197 29360040 details
RAB7A_HUMANGDIB_HUMANBioGRID26344197 29360040 details
RAB7A_HUMANNOTC1_HUMANBioGRID24662486 details
RAB7A_HUMANU2AF2_HUMANBioGRID26641092 details
RAB7A_HUMANTS101_HUMANBioGRID27764233 29859188 details
RAB7A_HUMANCHMP5_HUMANBioGRID27764233 details
RAB7A_HUMANMTSS1_HUMANBioGRID28264927 details
RAB7A_HUMANMON1A_HUMANBioGRID29360040 details
RAB7A_HUMANMON1B_HUMANBioGRID29360040 33144569 details
RAB7A_HUMANCCZ1B_HUMANBioGRID29360040 33144569 details
RAB7A_HUMANCCZ1_HUMANBioGRID29360040 33144569 details
RAB7A_HUMANACSL5_HUMANBioGRID29360040 details
RAB7A_HUMANK1C15_HUMANBioGRID29360040 details
RAB7A_HUMANSPG21_HUMANBioGRID29360040 details
RAB7A_HUMANREEP5_HUMANBioGRID29360040 details
RAB7A_HUMANTOM22_HUMANBioGRID29360040 details
RAB7A_HUMANRMC1_HUMANBioGRID29360040 33144569 details
RAB7A_HUMANRAB7A_HUMANBioGRID29360040 details
RAB7A_HUMANCE051_HUMANBioGRID29360040 details
RAB7A_HUMANPRAF3_HUMANBioGRID29360040 details
RAB7A_HUMANSNG2_HUMANBioGRID29360040 details
RAB7A_HUMANTOM40_HUMANBioGRID29360040 details
RAB7A_HUMANTPD52_HUMANBioGRID29360040 details
RAB7A_HUMANVATA_HUMANBioGRID29360040 details
RAB7A_HUMANESYT1_HUMANBioGRID29360040 details
RAB7A_HUMANUVRAG_HUMANBioGRID25533187 details
RAB7A_HUMANSZT2_HUMANBioGRID28199315 details
RAB7A_HUMANDEFI8_HUMANBioGRID27777970 details
RAB7A_HUMANFLCN_HUMANBioGRID28656962 details
RAB7A_HUMANMLP3A_HUMANBioGRID22496373 details
RAB7A_HUMANNREP_HUMANBioGRID25336651 details
RAB7A_HUMANST7_HUMANBioGRID29395067 details
RAB7A_HUMANNPC1_HUMANBioGRID33144569 details
RAB7A_HUMANPGTB2_HUMANHPRD11591706 details