Entity Details

Primary name KS6A3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51812
EntryNameKS6A3_HUMAN
FullNameRibosomal protein S6 kinase alpha-3
TaxID9606
Evidenceevidence at protein level
Length740
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesRPS6KA3

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001501 skeletal system development
GO:0002224 toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0007417 central nervous system development
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030307 positive regulation of cell growth
GO:0032496 response to lipopolysaccharide
GO:0035556 intracellular signal transduction
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043555 regulation of translation in response to stress
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0045202 synapse
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016239 Ribosomal protein S6 kinase IIFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR041905 Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domainDomainDomain
IPR041906 Ribosomal S6 kinase, N-terminal catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
300844 OMIMMental retardation, X-linked 19 (MRX19)A non-syndromic form of mild to moderate mental retardation. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. The disease is caused by variants affecting the gene represented in this entry.
303600 OMIMCoffin-Lowry syndrome (CLS)An X-linked mental retardation associated with facial and digital dysmorphisms, progressive skeletal malformations, growth retardation, hearing deficit and paroxysmal movement disorders. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
KS6A3_HUMANTAU_HUMANBioGRID, HPRD, MINT11181841 11311121 12387894 17512525 9353289 9546672 9832145 details
KS6A3_HUMANCSK2B_HUMANBioGRID, IntAct10094392 31980649 details
KS6A3_HUMANMK01_HUMANBioGRID, HPRD, IntAct12016217 12832467 18156174 21988832 23602568 25241761 31678930 31980649 8939914 9915826 details
KS6A3_HUMANATP5J_HUMANBioGRID, MINT21900206 details
KS6A3_HUMANBARX1_HUMANBioGRID, MINT21900206 details
KS6A3_HUMANEIF3C_HUMANBioGRID, MINT21900206 details
KS6A3_HUMANMASP1_HUMANBioGRID, MINT21900206 details
KS6A3_HUMANSPSY_HUMANBioGRID, MINT21900206 details
KS6A3_HUMANFYN_HUMANBioGRID, IntAct18156174 28514442 details
KS6A3_HUMANSPRE2_HUMANBioGRID, IntAct28514442 32814053 details
KS6A3_HUMAN5HT2A_HUMANDIP, HPRD16537434 details
KS6A3_HUMANPCNA_HUMANUniProt26030842 details
KS6A3_HUMANH31_HUMANBioGRID, IntAct10436156 31980649 details
KS6A3_HUMANNEK6_HUMANIntAct32814053 details
KS6A3_HUMANP85A_HUMANIntAct32814053 details
KS6A3_HUMANGNAO_HUMANIntAct32814053 details
KS6A3_HUMANPBIR3_HUMANIntAct32814053 details
KS6A3_HUMANBAG6_HUMANIntAct32814053 details
KS6A3_HUMANKLF11_HUMANIntAct32814053 details
KS6A3_HUMANPEA15_HUMANBioGRID, HPRD12796492 22213050 details
KS6A3_HUMANH2AX_HUMANBioGRID21224359 details
KS6A3_HUMANNEDD4_HUMANBioGRID19953087 details
KS6A3_HUMANYBOX1_HUMANBioGRID19036157 details
KS6A3_HUMANIKBA_HUMANBioGRID22685297 details
KS6A3_HUMANHMGN1_HUMANBioGRID, HPRD10739259 11438671 12773393 details
KS6A3_HUMANFGFR1_HUMANBioGRID24141780 details
KS6A3_HUMANILKAP_HUMANBioGRID29371914 details
KS6A3_HUMANFGFR3_HUMANBioGRID18156174 details
KS6A3_HUMANSRC_HUMANBioGRID18156174 details
KS6A3_HUMANFBX7_HUMANBioGRID27503909 details
KS6A3_HUMANP53_HUMANBioGRID15867353 details
KS6A3_HUMANCTND1_HUMANBioGRID31678930 details
KS6A3_HUMANSUMO2_HUMANBioGRID32786267 details
KS6A3_HUMANMAGI1_HUMANHPRD16217014 details
KS6A3_HUMANSHAN1_HUMANHPRD16217014 details
KS6A3_HUMANCRCM_HUMANIntAct17353931 details
KS6A3_HUMANGSTK1_HUMANIntAct17353931 details
KS6A3_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
KS6A3_HUMANMK03_HUMANBioGRID, HPRD, IntAct12832467 25241761 31980649 8939914 9915826 details
KS6A3_HUMANPDPK1_HUMANBioGRID, HPRD, IntAct10856237 25241761 details
KS6A3_HUMANPLD1_HUMANDIP18550821 details
KS6A3_HUMANH31T_HUMANBioGRID, HPRD, IntAct10436156 31980649 details
KS6A3_HUMANCBP_HUMANBioGRID, HPRD11564891 details
KS6A3_HUMANMK14_HUMANBioGRID11157753 details
KS6A3_HUMANESR1_HUMANBioGRID, HPRD11139588 11432835 11507039 9528769 details
KS6A3_HUMANNFAC1_HUMANBioGRID22113269 details
KS6A3_HUMANTRAF2_HUMANBioGRID22685297 details
KS6A3_HUMANFOXN2_HUMANBioGRID29396548 details
KS6A3_HUMANKS6A3_HUMANBioGRID, HPRD17192257 31980649 details
KS6A3_HUMANDCP1A_HUMANBioGRID29395067 details
KS6A3_HUMANNR4A1_HUMANHPRD16223362 details
KS6A3_HUMANSTK11_HUMANHPRD11297520 11853558 details
KS6A3_HUMANNMDE4_HUMANHPRD10862698 details
KS6A3_HUMANNMDZ1_HUMANHPRD10862698 details
KS6A3_HUMANBAD_HUMANHPRD11544290 details
KS6A3_HUMANFGF2_HUMANHPRD15879597 details
KS6A3_HUMANCREB1_HUMANHPRD11160957 11175347 8688081 9687510 9829964 details
KS6A3_HUMANK1C18_HUMANHPRD1374067 7523419 details
KS6A3_HUMANHMGN2_HUMANHPRD11438671 details