Entity Details

Primary name AK1D1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51857
EntryNameAK1D1_HUMAN
FullNameAldo-keto reductase family 1 member D1
TaxID9606
Evidenceevidence at protein level
Length326
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesAKR1D1

GO terms

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GOName
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0005496 steroid binding
GO:0005829 cytosol
GO:0006699 bile acid biosynthetic process
GO:0006707 cholesterol catabolic process
GO:0007586 digestion
GO:0008202 steroid metabolic process
GO:0008207 C21-steroid hormone metabolic process
GO:0008209 androgen metabolic process
GO:0016229 steroid dehydrogenase activity
GO:0030573 bile acid catabolic process
GO:0047086 ketosteroid monooxygenase activity
GO:0047787 delta4-3-oxosteroid 5beta-reductase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR018170 Aldo/keto reductase, conserved siteSiteConserved site
IPR020471 Aldo-keto reductaseFamilyFamily
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily
IPR044483 Aldo-keto reductase family 1 member D1FamilyFamily

Diseases

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Disease IDSourceNameDescription
235555 OMIMCongenital bile acid synthesis defect 2 (CBAS2)A condition characterized by jaundice, intrahepatic cholestasis and hepatic failure. Patients with this liver disease show absence or low levels of chenodeoxycholic acid and cholic acid in plasma and urine. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00548 Azelaic acidDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB01216 FinasterideDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB07447 5beta-dihydrotestosteroneDrugbanksmall molecule
DB07557 3,20-PregnanedioneDrugbanksmall molecule

Interactions

0 interactions

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