Entity Details

Primary name 6PGD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52209
EntryName6PGD_HUMAN
FullName6-phosphogluconate dehydrogenase, decarboxylating
TaxID9606
Evidenceevidence at protein level
Length483
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPGD

GO terms

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GOName
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006098 pentose-phosphate shunt
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0019322 pentose biosynthetic process
GO:0046177 D-gluconate catabolic process
GO:0050661 NADP binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR006113 6-phosphogluconate dehydrogenase, decarboxylatingFamilyFamily
IPR006114 6-phosphogluconate dehydrogenase, C-terminalDomainDomain
IPR006115 6-phosphogluconate dehydrogenase, NADP-bindingDomainDomain
IPR006183 6-phosphogluconate dehydrogenaseFamilyFamily
IPR006184 6-phosphogluconate-binding siteSiteBinding site
IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR013328 6-phosphogluconate dehydrogenase, domain 2FamilyHomologous superfamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00563 MethotrexateDrugbanksmall molecule
DB00695 FurosemideDrugbanksmall molecule
DB00789 Gadopentetic acidDrugbanksmall molecule
DB00814 MeloxicamDrugbanksmall molecule
DB00851 DacarbazineDrugbanksmall molecule
DB00867 RitodrineDrugbanksmall molecule
DB00920 KetotifenDrugbanksmall molecule
DB02076 6-phospho-D-gluconic acidDrugbanksmall molecule
DB03962 Nicotinamide 8-bromo-adenine dinucleotide phosphateDrugbanksmall molecule