Entity Details

Primary name KIF11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52732
EntryNameKIF11_HUMAN
FullNameKinesin-like protein KIF11
TaxID9606
Evidenceevidence at protein level
Length1056
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesKIF11

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0000922 spindle pole
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005819 spindle
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0007018 microtubule-based movement
GO:0007051 spindle organization
GO:0007052 mitotic spindle organization
GO:0007100 mitotic centrosome separation
GO:0008017 microtubule binding
GO:0008574 plus-end-directed microtubule motor activity
GO:0016020 membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0032991 protein-containing complex
GO:0046602 regulation of mitotic centrosome separation
GO:0051301 cell division
GO:0072686 mitotic spindle
GO:0090307 mitotic spindle assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001752 Kinesin motor domainDomainDomain
IPR019821 Kinesin motor domain, conserved siteSiteConserved site
IPR025901 Kinesin-associated microtubule-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036961 Kinesin motor domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
152950 OMIMMicrocephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB03996 3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]PhenolDrugbanksmall molecule
DB04331 MonastrolDrugbanksmall molecule
DB06040 FilanesibDrugbanksmall molecule
DB07064 (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDEDrugbanksmall molecule
DB08032 N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDEDrugbanksmall molecule
DB08033 (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDEDrugbanksmall molecule
DB08037 MK-0731Drugbanksmall molecule
DB08198 [(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONEDrugbanksmall molecule
DB08239 (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDEDrugbanksmall molecule
DB08244 (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINEDrugbanksmall molecule
DB08246 (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDEDrugbanksmall molecule
DB08250 (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDEDrugbanksmall molecule