Entity Details

Primary name HXK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52789
EntryNameHXK2_HUMAN
FullNameHexokinase-2
TaxID9606
Evidenceevidence at protein level
Length917
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesHK2

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001678 cellular glucose homeostasis
GO:0002931 response to ischemia
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005524 ATP binding
GO:0005536 glucose binding
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0007595 lactation
GO:0008637 apoptotic mitochondrial changes
GO:0008865 fructokinase activity
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0019158 mannokinase activity
GO:0035795 negative regulation of mitochondrial membrane permeability
GO:0043231 intracellular membrane-bounded organelle
GO:0045766 positive regulation of angiogenesis
GO:0046324 regulation of glucose import
GO:0051156 glucose 6-phosphate metabolic process
GO:0061621 canonical glycolysis
GO:0072655 establishment of protein localization to mitochondrion
GO:0072656 maintenance of protein location in mitochondrion
GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR001312 HexokinaseFamilyFamily
IPR019807 Hexokinase, binding siteSiteBinding site
IPR022672 Hexokinase, N-terminalDomainDomain
IPR022673 Hexokinase, C-terminalDomainDomain
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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