Entity Details

Primary name BIEA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53004
EntryNameBIEA_HUMAN
FullNameBiliverdin reductase A
TaxID9606
Evidenceevidence at protein level
Length296
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesBLVRA

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0004074 biliverdin reductase (NAD(P)+) activity
GO:0005829 cytosol
GO:0008270 zinc ion binding
GO:0042167 heme catabolic process
GO:0070062 extracellular exosome
GO:0106276 biliberdin reductase NAD+ activity
GO:0106277 biliverdin reductase (NADP+) activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000683 Gfo/Idh/MocA-like oxidoreductase, N-terminalDomainDomain
IPR015249 Biliverdin reductase, catalyticDomainDomain
IPR017094 Biliverdin reductase AFamilyFamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614156 OMIMHyperbiliverdinemia (HBLVD)A condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule