Entity Details

Primary name SYRC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54136
EntryNameSYRC_HUMAN
FullNameArginine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length660
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesRARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0004814 arginine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006420 arginyl-tRNA aminoacylation
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0034618 arginine binding
GO:0045296 cadherin binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001278 Arginine-tRNA ligaseFamilyFamily
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR005148 Arginyl tRNA synthetase N-terminal domainDomainDomain
IPR008909 DALR anticodon bindingDomainDomain
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR035684 Arginyl-tRNA synthetase, catalytic core domainDomainDomain
IPR036695 Arginyl tRNA synthetase N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616140 OMIMLeukodystrophy, hypomyelinating, 9 (HLD9)An autosomal recessive neurodegenerative disorder characterized by delayed psychomotor development, severe spasticity, nystagmus, and ataxia associated with diffuse hypomyelination apparent on brain MRI. The disease is caused by variants affecting the gene represented in this entry.