Entity Details

Primary name FGF8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55075
EntryNameFGF8_HUMAN
FullNameFibroblast growth factor 8
TaxID9606
Evidenceevidence at protein level
Length233
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesFGF8

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001759 organ induction
GO:0001823 mesonephros development
GO:0001839 neural plate morphogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001947 heart looping
GO:0001974 blood vessel remodeling
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0005104 fibroblast growth factor receptor binding
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006979 response to oxidative stress
GO:0007369 gastrulation
GO:0008045 motor neuron axon guidance
GO:0008078 mesodermal cell migration
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008406 gonad development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0009887 animal organ morphogenesis
GO:0009897 external side of plasma membrane
GO:0009953 dorsal/ventral pattern formation
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0021543 pallium development
GO:0021544 subpallium development
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021846 cell proliferation in forebrain
GO:0021884 forebrain neuron development
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030334 regulation of cell migration
GO:0030539 male genitalia development
GO:0030878 thyroid gland development
GO:0030916 otic vesicle formation
GO:0030917 midbrain-hindbrain boundary development
GO:0033563 dorsal/ventral axon guidance
GO:0035050 embryonic heart tube development
GO:0035108 limb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035909 aorta morphogenesis
GO:0042056 chemoattractant activity
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0043524 negative regulation of neuron apoptotic process
GO:0045165 cell fate commitment
GO:0045597 positive regulation of cell differentiation
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045840 positive regulation of mitotic nuclear division
GO:0046622 positive regulation of organ growth
GO:0048702 embryonic neurocranium morphogenesis
GO:0048853 forebrain morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0060037 pharyngeal system development
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060348 bone development
GO:0060425 lung morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060563 neuroepithelial cell differentiation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071542 dopaminergic neuron differentiation
GO:0090134 cell migration involved in mesendoderm migration
GO:0120223 larynx morphogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002209 Fibroblast growth factor familyFamilyFamily
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR028249 Fibroblast growth factor 8FamilyFamily

Diseases

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Disease IDSourceNameDescription
612702 OMIMHypogonadotropic hypogonadism 6 with or without anosmia (HH6)A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in FGF8 as well as in other HH-associated genes including FGFR1 (PubMed:23643382).

Interactions

5 interactions