Entity Details

Primary name PER3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP56645
EntryNamePER3_HUMAN
FullNamePeriod circadian protein homolog 3
TaxID9606
Evidenceevidence at protein level
Length1201
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesPER3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0001222 transcription corepressor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032922 circadian regulation of gene expression
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0050821 protein stabilization

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR013655 PAS fold-3DomainDomain
IPR015524 Period circadian protein 3FamilyFamily
IPR022728 Period circadian-like, C-terminalDomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616882 OMIMAdvanced sleep phase syndrome, familial, 3 (FASPS3)A disorder characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms. The disease is caused by variants affecting the gene represented in this entry.