Entity Details

Primary name SIK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP57059
EntryNameSIK1_HUMAN
FullNameSerine/threonine-protein kinase SIK1
TaxID9606
Evidenceevidence at protein level
Length783
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSIK1B
SIK1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0002028 regulation of sodium ion transport
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008140 cAMP response element binding protein binding
GO:0010830 regulation of myotube differentiation
GO:0010868 negative regulation of triglyceride biosynthetic process
GO:0019901 protein kinase binding
GO:0032792 negative regulation of CREB transcription factor activity
GO:0035556 intracellular signal transduction
GO:0042149 cellular response to glucose starvation
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045595 regulation of cell differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
GO:0048511 rhythmic process
GO:0055007 cardiac muscle cell differentiation
GO:0071889 14-3-3 protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000210 positive regulation of anoikis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017090 Serine/threonine-protein kinase, SIK1/2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034672 Salt-Inducible kinase, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616341 OMIMDevelopmental and epileptic encephalopathy 30 (DEE30)A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB08912 DabrafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule