Entity Details

Primary name TMPS3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP57727
EntryNameTMPS3_HUMAN
FullNameTransmembrane protease serine 3
TaxID9606
Evidenceevidence at protein level
Length454
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesTMPRSS3

GO terms

Show/Hide Table
GOName
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006508 proteolysis
GO:0006883 cellular sodium ion homeostasis
GO:0007605 sensory perception of sound
GO:0016021 integral component of membrane
GO:0017080 sodium channel regulator activity
GO:0043025 neuronal cell body

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001190 SRCR domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR017448 SRCR-like domainDomainDomain
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036772 SRCR-like domain superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
601072 OMIMDeafness, autosomal recessive, 8 (DFNB8)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
TMPS3_HUMANEF1A1_HUMANBioGRID, HPRD, IntAct16169070 details
TMPS3_HUMANRXRA_HUMANBioGRID, HPRD, IntAct16169070 details
TMPS3_HUMANTMED7_HUMANBioGRID, IntAct21988832 details