Entity Details

Primary name TPIS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP60174
EntryNameTPIS_HUMAN
FullNameTriosephosphate isomerase
TaxID9606
Evidenceevidence at protein level
Length249
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTPI1

GO terms

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GOName
GO:0004807 triose-phosphate isomerase activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0007275 multicellular organism development
GO:0008929 methylglyoxal synthase activity
GO:0019242 methylglyoxal biosynthetic process
GO:0019563 glycerol catabolic process
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0046166 glyceraldehyde-3-phosphate biosynthetic process
GO:0061621 canonical glycolysis
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000652 Triosephosphate isomeraseFamilyFamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR020861 Triosephosphate isomerase, active siteSiteActive site
IPR022896 Triosephosphate isomerase, bacterial/eukaryoticFamilyFamily
IPR035990 Triosephosphate isomerase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615512 OMIMTriosephosphate isomerase deficiency (TPID)An autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB01695 N-Hydroxy-4-Phosphono-ButanamideDrugbanksmall molecule
DB02726 2-Phosphoglycolic AcidDrugbanksmall molecule
DB03026 Phosphoglycolohydroxamic AcidDrugbanksmall molecule
DB03132 3-(2-Benzothiazolylthio)-1-Propanesulfonic AcidDrugbanksmall molecule
DB03135 [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic AcidDrugbanksmall molecule
DB03314 5-fluorotryptophanDrugbanksmall molecule
DB03379 2-Carboxyethylphosphonic AcidDrugbanksmall molecule
DB03900 tert-butanolDrugbanksmall molecule
DB04326 Dihydroxyacetone phosphateDrugbanksmall molecule
DB04447 1,4-DithiothreitolDrugbanksmall molecule
DB04510 3-phospho-D-glyceric acidDrugbanksmall molecule
DB07387 3-(BUTYLSULPHONYL)-PROPANOIC ACIDDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule