Entity Details

Primary name ISL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61371
EntryNameISL1_HUMAN
FullNameInsulin gene enhancer protein ISL-1
TaxID9606
Evidenceevidence at protein level
Length349
SequenceStatuscomplete
DateCreated2004-05-24
DateModified2021-06-02

Ontological Relatives

GenesISL1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001755 neural crest cell migration
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007409 axonogenesis
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016922 nuclear receptor binding
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021522 spinal cord motor neuron differentiation
GO:0021524 visceral motor neuron differentiation
GO:0021559 trigeminal nerve development
GO:0021983 pituitary gland development
GO:0030331 estrogen receptor binding
GO:0031016 pancreas development
GO:0031103 axon regeneration
GO:0031290 retinal ganglion cell axon guidance
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032024 positive regulation of insulin secretion
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035066 positive regulation of histone acetylation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043388 positive regulation of DNA binding
GO:0043425 bHLH transcription factor binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048665 neuron fate specification
GO:0048762 mesenchymal cell differentiation
GO:0048880 sensory system development
GO:0048936 peripheral nervous system neuron axonogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060037 pharyngeal system development
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060384 innervation
GO:0060413 atrial septum morphogenesis
GO:0060913 cardiac cell fate determination
GO:0060931 sinoatrial node cell development
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071657 positive regulation of granulocyte colony-stimulating factor production
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901258 positive regulation of macrophage colony-stimulating factor production
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR001781 Zinc finger, LIM-typeDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
ISL1_HUMANCDN2B_HUMANBioGRID, IntAct21988832 details
ISL1_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
ISL1_HUMANTF65_HUMANBioGRID, IntAct21988832 details
ISL1_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
ISL1_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
ISL1_HUMANPLCG2_HUMANBioGRID, IntAct25814554 details
ISL1_HUMANCRK_HUMANBioGRID, IntAct25814554 details
ISL1_HUMANZN511_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ISL1_HUMANLDB1_HUMANBioGRID, HPRD, IntAct20211142 24981860 32296183 9452425 details
ISL1_HUMANLHX4_HUMANBioGRID, IntAct20211142 26186194 28514442 31515488 details
ISL1_HUMANSSBP4_HUMANBioGRID, IntAct20211142 24981860 26186194 28514442 details
ISL1_HUMANGEMI_HUMANIntAct22615398 details
ISL1_HUMANLDB2_HUMANBioGRID, IntAct20211142 details
ISL1_HUMANISL1_HUMANBioGRID9452425 details
ISL1_HUMANLMX1A_HUMANBioGRID, HPRD9452425 details
ISL1_HUMANLHX3_HUMANBioGRID, HPRD9452425 details
ISL1_HUMANISL2_HUMANBioGRID, HPRD9452425 details
ISL1_HUMANRBTN2_HUMANBioGRID, HPRD9452425 details
ISL1_HUMANESR1_HUMANBioGRID, HPRD11043578 details
ISL1_HUMANPECR_HUMANBioGRID, HPRD11043578 details
ISL1_HUMANCOT1_HUMANBioGRID, HPRD11043578 details
ISL1_HUMANA4_HUMANBioGRID21832049 details
ISL1_HUMANHNF4A_HUMANBioGRID17022998 details
ISL1_HUMANMAFA_HUMANBioGRID26180087 details
ISL1_HUMANMAFB_HUMANBioGRID26180087 details
ISL1_HUMANBRE1A_HUMANBioGRID31186351 details
ISL1_HUMANBRE1B_HUMANBioGRID31186351 details
ISL1_HUMANRNF12_HUMANHPRD10431247 11882901 details
ISL1_HUMANLHX1_HUMANHPRD9452425 details