Entity Details

Primary name RHOA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61586
EntryNameRHOA_HUMAN
FullNameTransforming protein RhoA
TaxID9606
Evidenceevidence at protein level
Length193
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesRHOA

GO terms

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GOName
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0007015 actin filament organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0010812 negative regulation of cell-substrate adhesion
GO:0016032 viral process
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0017022 myosin binding
GO:0019901 protein kinase binding
GO:0021762 substantia nigra development
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030054 cell junction
GO:0030334 regulation of cell migration
GO:0030496 midbody
GO:0030667 secretory granule membrane
GO:0030865 cortical cytoskeleton organization
GO:0031122 cytoplasmic microtubule organization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0031532 actin cytoskeleton reorganization
GO:0031982 vesicle
GO:0032154 cleavage furrow
GO:0032467 positive regulation of cytokinesis
GO:0032956 regulation of actin cytoskeleton organization
GO:0033688 regulation of osteoblast proliferation
GO:0034329 cell junction assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035385 Roundabout signaling pathway
GO:0036089 cleavage furrow formation
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042995 cell projection
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043149 stress fiber assembly
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043296 apical junction complex
GO:0043297 apical junction assembly
GO:0043312 neutrophil degranulation
GO:0043542 endothelial cell migration
GO:0043931 ossification involved in bone maturation
GO:0044319 wound healing, spreading of cells
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045666 positive regulation of neuron differentiation
GO:0045792 negative regulation of cell size
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050919 negative chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051496 positive regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060193 positive regulation of lipase activity
GO:0061383 trabecula morphogenesis
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071345 cellular response to cytokine stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0071944 cell periphery
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090307 mitotic spindle assembly
GO:0097498 endothelial tube lumen extension
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0101003 ficolin-1-rich granule membrane
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902766 skeletal muscle satellite cell migration
GO:1903673 mitotic cleavage furrow formation
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
GO:1990869 cellular response to chemokine
GO:2000145 regulation of cell motility
GO:2000406 positive regulation of T cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cleavage furrow
Cytoplasm
Midbody

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR003578 Small GTPase RhoFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618727 OMIMEctodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies (EDFAOB)A neuroectodermal syndrome characterized by linear hypopigmentation, alopecia, apparently asymptomatic leukoencephalopathy, and facial, ocular, dental and acral anomalies. Patients show no intellectual or neurologic impairment. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule

Interactions

164 interactions

InteractorPartnerSourcesPublicationsLink
RHOA_HUMANPKN1_HUMANBioGRID, HPRD, MINT10619026 12773565 8571127 9446575 9535835 details
RHOA_HUMANRTKN_HUMANBioGRID, DIP, HPRD, IntAct, MINT12593858 12879077 14506264 14749388 15075243 18256687 19147496 19696020 19805522 19944695 22621765 22693251 22705156 25150978 26825171 27775029 8662891 details
RHOA_HUMANCNKR1_HUMANBioGRID, HPRD, MINT14749388 15670823 details
RHOA_HUMANUBC_HUMANBioGRID, MINT15710384 25411243 details
RHOA_HUMANSMUF1_HUMANBioGRID, HPRD, MINT15710384 16472676 16622418 21708152 26825171 28169289 28294307 28658604 31623230 details
RHOA_HUMANARHG5_HUMANBioGRID, IntAct12006984 32203420 details
RHOA_HUMANRHG01_HUMANBioGRID, HPRD, IntAct11927263 14749388 16189514 20660160 31467278 9407060 9535855 9548756 details
RHOA_HUMANGDIR1_HUMANBioGRID, HPRD, IntAct10489445 11149925 11368848 14749388 15659383 17353931 20628200 20711218 25416956 26344197 26719334 30287810 9490022 details
RHOA_HUMANROCK1_HUMANBioGRID, HPRD, IntAct, MINT12773565 14660612 21281639 31431478 8798490 8816443 details
RHOA_HUMANARHGC_HUMANBioGRID, HPRD, IntAct, MINT11373293 15364580 20300064 23405219 28514442 32203420 details
RHOA_HUMANSMUF2_HUMANBioGRID, IntAct17719543 20026602 21402695 details
RHOA_HUMANNGEF_HUMANBioGRID, MINT18256687 32203420 details
RHOA_HUMANARHGJ_HUMANBioGRID, MINT18256687 32203420 details
RHOA_HUMANVAV_HUMANBioGRID, HPRD, MINT16397238 18511940 32203420 details
RHOA_HUMANOTUB1_HUMANBioGRID, MINT20553488 details
RHOA_HUMANSMAD2_HUMANBioGRID, IntAct20195357 details
RHOA_HUMANARHGB_HUMANBioGRID, DIP, HPRD, IntAct, MINT10526156 15530360 20300064 21988832 28514442 32203420 details
RHOA_HUMANRIPR2_HUMANBioGRID, IntAct21516116 21988832 25416956 32296183 details
RHOA_HUMANRPN2_HUMANBioGRID, IntAct21988832 details
RHOA_HUMANRACK1_HUMANBioGRID, IntAct21988832 details
RHOA_HUMANMPRIP_HUMANBioGRID, HPRD, MINT14506264 15545284 9199174 details
RHOA_HUMANMYO9B_HUMANUniProt15644318 details
RHOA_HUMANDIAP1_HUMANBioGRID, HPRD, mbinfo12773565 15864301 16109481 18218625 details
RHOA_HUMANDAAM1_HUMANBioGRID, DIP, HPRD, IntAct, mbinfo11779461 18162551 18218625 25241761 28514442 details
RHOA_HUMANAP2A_HUMANIntAct24835590 details
RHOA_HUMANTRIP6_HUMANBioGRID, IntAct25416956 details
RHOA_HUMANIKZF3_HUMANBioGRID, IntAct25416956 details
RHOA_HUMANARHG2_HUMANBioGRID, HPRD, IntAct22072711 28514442 32296183 9857026 details
RHOA_HUMANANS1B_HUMANBioGRID, IntAct32296183 details
RHOA_HUMANRIPR3_HUMANBioGRID, IntAct32296183 details
RHOA_HUMANARHG1_HUMANBioGRID, IntAct12748184 28514442 32203420 details
RHOA_HUMANPKN2_HUMANBioGRID, HPRD, IntAct28514442 8910519 9121475 9446575 details
RHOA_HUMANGDS1_HUMANBioGRID, HPRD, IntAct11948427 20709748 28514442 31980649 details
RHOA_HUMANCDN1B_HUMANBioGRID, DIP19470470 23333463 details
RHOA_HUMANRHG35_HUMANBioGRID, IntAct15102857 31623230 32203420 9535855 9548756 details
RHOA_HUMANMCF2_HUMANBioGRID, HPRD, IntAct10854437 32203420 details
RHOA_HUMANA4_HUMANIntAct32814053 details
RHOA_HUMANPDE6D_HUMANBioGRID, HPRD11786539 details
RHOA_HUMANARHGP_HUMANBioGRID, HPRD15069594 32203420 details
RHOA_HUMANDEFI6_HUMANBioGRID, HPRD15023524 details
RHOA_HUMANRHG32_HUMANBioGRID12446789 12454018 12857875 details
RHOA_HUMANRHG05_HUMANBioGRID, HPRD12842009 32203420 9407060 details
RHOA_HUMANCTRO_HUMANBioGRID, HPRD12773565 8543060 details
RHOA_HUMANRHPN2_HUMANBioGRID, HPRD12221077 12773565 details
RHOA_HUMANKTN1_HUMANBioGRID11162552 11689693 12773565 8769096 details
RHOA_HUMANITPR1_HUMANBioGRID, HPRD12766172 details
RHOA_HUMANTRPC1_HUMANBioGRID, HPRD12766172 details
RHOA_HUMANPLD1_HUMANBioGRID, HPRD11311142 12593858 9565577 details
RHOA_HUMANARHG8_HUMANBioGRID32203420 9535835 details
RHOA_HUMANPLCG1_HUMANBioGRID, HPRD12071848 details
RHOA_HUMANARHG3_HUMANBioGRID, HPRD12221096 details
RHOA_HUMANAKP13_HUMANBioGRID, HPRD11696353 12423633 19696020 32203420 details
RHOA_HUMANICMT_HUMANBioGRID, HPRD9614111 details
RHOA_HUMANVAV3_HUMANBioGRID, HPRD10523675 32203420 details
RHOA_HUMANARHGI_HUMANBioGRID, HPRD11085924 details
RHOA_HUMANRHG26_HUMANBioGRID11432776 32203420 details
RHOA_HUMANRHG10_HUMANBioGRID11432776 32203420 details
RHOA_HUMANKCNA2_HUMANBioGRID, HPRD9635436 details
RHOA_HUMANARHG4_HUMANBioGRID, HPRD10947987 32203420 details
RHOA_HUMANOPHN1_HUMANBioGRID, HPRD11998687 9582072 details
RHOA_HUMANDGKQ_HUMANBioGRID, HPRD10066731 details
RHOA_HUMANTRIO_HUMANBioGRID, HPRD10948190 26344197 details
RHOA_HUMANPKHG2_HUMANBioGRID, HPRD11839748 details
RHOA_HUMANGDIR3_HUMANBioGRID, HPRD26344197 9113980 details
RHOA_HUMANMCF2L_HUMANBioGRID, HPRD12006984 32203420 details
RHOA_HUMANBCR_HUMANBioGRID9535855 details
RHOA_HUMANCAV1_HUMANBioGRID, HPRD20460433 9647788 details
RHOA_HUMANM3K1_HUMANBioGRID14581471 21129722 24135036 details
RHOA_HUMANDIAP3_HUMANBioGRID15085137 details
RHOA_HUMANBIRC2_HUMANBioGRID24276241 details
RHOA_HUMANNEMO_HUMANBioGRID24240172 details
RHOA_HUMANBACD1_HUMANBioGRID19782033 26100637 details
RHOA_HUMANBACD2_HUMANBioGRID19782033 details
RHOA_HUMANDCNL1_HUMANBioGRID25411243 details
RHOA_HUMANRHPN1_HUMANBioGRID, HPRD12221077 14749388 details
RHOA_HUMANRASF1_HUMANBioGRID26825171 details
RHOA_HUMANANLN_HUMANBioGRID25959226 details
RHOA_HUMANSHLB2_HUMANBioGRID16849557 details
RHOA_HUMANAGAP2_HUMANBioGRID22453919 details
RHOA_HUMANAGAP1_HUMANBioGRID22453919 details
RHOA_HUMANRASK_HUMANBioGRID27229929 30194290 details
RHOA_HUMANNOTC1_HUMANBioGRID27229929 details
RHOA_HUMANLRP2_HUMANBioGRID18426980 details
RHOA_HUMANBMAL1_HUMANBioGRID30287810 details
RHOA_HUMANCLOCK_HUMANBioGRID30287810 details
RHOA_HUMANFMN2_HUMANBioGRID29659741 details
RHOA_HUMANPTPRF_HUMANBioGRID25458010 details
RHOA_HUMANS13A1_HUMANBioGRID18407958 details
RHOA_HUMANARHGA_HUMANBioGRID32203420 details
RHOA_HUMANARHGF_HUMANBioGRID32203420 details
RHOA_HUMANARHGH_HUMANBioGRID32203420 details
RHOA_HUMANARG28_HUMANBioGRID, HPRD32203420 9199174 details
RHOA_HUMANPKHG4_HUMANBioGRID32203420 details
RHOA_HUMANPKHG6_HUMANBioGRID32203420 details
RHOA_HUMANPREX1_HUMANBioGRID32203420 details
RHOA_HUMANPREX2_HUMANBioGRID32203420 details
RHOA_HUMANRGRF2_HUMANBioGRID32203420 details
RHOA_HUMANTIAM1_HUMANBioGRID32203420 details
RHOA_HUMANARAP2_HUMANBioGRID32203420 details
RHOA_HUMANRHGBA_HUMANBioGRID32203420 details
RHOA_HUMANRHGBB_HUMANBioGRID32203420 details
RHOA_HUMANRHG19_HUMANBioGRID32203420 details
RHOA_HUMANRHG20_HUMANBioGRID32203420 details
RHOA_HUMANRHG21_HUMANBioGRID, HPRD15793564 32203420 details
RHOA_HUMANRHG22_HUMANBioGRID32203420 details
RHOA_HUMANRHG23_HUMANBioGRID32203420 details
RHOA_HUMANRHG29_HUMANBioGRID32203420 details
RHOA_HUMANRHG31_HUMANBioGRID32203420 details
RHOA_HUMANRHG07_HUMANBioGRID32203420 details
RHOA_HUMANGMIP_HUMANBioGRID, HPRD12093360 32203420 details
RHOA_HUMANMYO9A_HUMANBioGRID32203420 details
RHOA_HUMANSTAR8_HUMANBioGRID32203420 details
RHOA_HUMANPRAF1_HUMANHPRD11335720 details
RHOA_HUMANHLAB_HUMANIntAct17353931 details
RHOA_HUMANRAGE_HUMANMINT19944695 details
RHOA_HUMANNUCL_HUMANMINT21281639 details
RHOA_HUMANMYPT1_HUMANBioGRID, HPRD, MINT15545284 22939629 9354661 details
RHOA_HUMANRHOA_HUMANBioGRID, HPRD, mbinfo15069594 31980649 9748241 details
RHOA_HUMANLRRK2_HUMANBioGRID, IntAct21454543 31046837 details
RHOA_HUMANTNR6_HUMANBioGRID, IntAct15659383 25241761 details
RHOA_HUMANFADD_HUMANBioGRID, IntAct15659383 25241761 details
RHOA_HUMANBID_HUMANBioGRID, IntAct15659383 25241761 details
RHOA_HUMANMK08_HUMANBioGRID, IntAct15659383 25241761 details
RHOA_HUMANHMHA1_HUMANIntAct24086303 details
RHOA_HUMANTRI65_HUMANMINT27829229 details
RHOA_HUMANHS71A_HUMANBioGRID, HPRD, IntAct12490434 31980649 details
RHOA_HUMANTR10B_HUMANBioGRID15659383 details
RHOA_HUMANEZRI_HUMANBioGRID15659383 details
RHOA_HUMANTNFL6_HUMANBioGRID15659383 details
RHOA_HUMANMOES_HUMANBioGRID15659383 details
RHOA_HUMANCASPA_HUMANBioGRID15659383 details
RHOA_HUMANCASP8_HUMANBioGRID15659383 details
RHOA_HUMANTNR1A_HUMANBioGRID15659383 details
RHOA_HUMANHS71B_HUMANBioGRID, HPRD12490434 31980649 details
RHOA_HUMANROCK2_HUMANBioGRID11350930 details
RHOA_HUMANPLXB1_HUMANBioGRID19805522 details
RHOA_HUMANCUL3_HUMANBioGRID19782033 28499918 30287810 details
RHOA_HUMANSRGP1_HUMANBioGRID, HPRD11672528 20856855 details
RHOA_HUMAN5HT1A_HUMANBioGRID17142836 details
RHOA_HUMANMDM2_HUMANBioGRID22907703 details
RHOA_HUMANPSD10_HUMANBioGRID20628200 details
RHOA_HUMANMARK2_HUMANBioGRID22072711 details
RHOA_HUMANBAIP2_HUMANBioGRID11157984 details
RHOA_HUMANGDIR2_HUMANBioGRID, HPRD26344197 9799233 details
RHOA_HUMANS10A4_HUMANBioGRID26825171 details
RHOA_HUMANU2AF2_HUMANBioGRID26641092 details
RHOA_HUMANPTEN_HUMANBioGRID22720799 details
RHOA_HUMANCCM2_HUMANBioGRID31623230 details
RHOA_HUMANPKHG5_HUMANBioGRID20811643 details
RHOA_HUMANKPCA_HUMANHPRD11284700 details
RHOA_HUMANTGM2_HUMANHPRD11350930 details
RHOA_HUMANFLNA_HUMANHPRD10051605 details
RHOA_HUMANVAV2_HUMANHPRD11909943 details
RHOA_HUMANKAPCA_HUMANHPRD12654918 details
RHOA_HUMANCNTP1_HUMANHPRD9407060 details
RHOA_HUMAN3BP1_HUMANHPRD9548756 details
RHOA_HUMANDOCK7_HUMANHPRD12432077 details
RHOA_HUMANSPRE2_HUMANHPRD15184877 details
RHOA_HUMANRGRF1_HUMANHPRD10220378 details
RHOA_HUMANRHG08_HUMANHPRD12944407 details
RHOA_HUMANPITM1_HUMANHPRD15125835 details
RHOA_HUMANTGFR1_HUMANHPRD15761153 details
RHOA_HUMANKPCZ_HUMANHPRD15210811 details
RHOA_HUMANDVL2_HUMANHPRD12533515 details