Entity Details

Primary name PRS8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62195
EntryNamePRS8_HUMAN
FullName26S proteasome regulatory subunit 8
TaxID9606
Evidenceevidence at protein level
Length406
SequenceStatuscomplete
DateCreated2004-06-21
DateModified2021-06-02

Ontological Relatives

GenesPSMC5

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008134 transcription factor binding
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0016234 inclusion body
GO:0016579 protein deubiquitination
GO:0016887 ATP hydrolysis activity
GO:0017025 TBP-class protein binding
GO:0022624 proteasome accessory complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031410 cytoplasmic vesicle
GO:0031531 thyrotropin-releasing hormone receptor binding
GO:0031595 nuclear proteasome complex
GO:0031597 cytosolic proteasome complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0036402 proteasome-activating activity
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043069 negative regulation of programmed cell death
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0050804 modulation of chemical synaptic transmission
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0072562 blood microparticle
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090261 positive regulation of inclusion body assembly
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098794 postsynapse
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR005937 26S proteasome regulatory subunit P45-likeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032501 Proteasomal ATPase OB C-terminal domainDomainDomain
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

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Interactions

144 interactions

InteractorPartnerSourcesPublicationsLink
PRS8_HUMANPSMD2_HUMANBioGRID, IntAct, MINT16763564 17646385 19490896 22275368 22939629 26344197 28292943 28514442 details
PRS8_HUMANPHLP_HUMANBioGRID, IntAct, MINT15604093 21516116 25416956 28514442 29892012 31515488 32296183 32814053 details
PRS8_HUMANKRT38_HUMANBioGRID, IntAct25416956 29892012 31515488 details
PRS8_HUMANPSDE_HUMANBioGRID, IntAct17323924 22863883 22939629 26337389 26344197 26496610 27428775 28292943 28514442 28821611 30745168 details
PRS8_HUMANUBC_HUMANBioGRID14706819 16196087 28190767 details
PRS8_HUMANESR1_HUMANBioGRID, HPRD14702340 8598193 details
PRS8_HUMANERPG3_HUMANBioGRID26030138 31722399 details
PRS8_HUMANERCC6_HUMANBioGRID26030138 31722399 details
PRS8_HUMANPRS6B_HUMANBioGRID, HPRD, IntAct15604093 16189514 17353931 19490896 19781552 22275368 22863883 22939629 26344197 28292943 28514442 29892012 31515488 32296183 details
PRS8_HUMANPRS10_HUMANBioGRID, DIP, IntAct, MINT11361004 16763564 19490896 22275368 22863883 22939629 26344197 27342858 28292943 28514442 29636472 32296183 details
PRS8_HUMANPRS7_HUMANBioGRID, IntAct, MINT16763564 19490896 21628461 22275368 22901813 22939629 26344197 28292943 28514442 9464850 details
PRS8_HUMANERCC3_HUMANBioGRID, HPRD, IntAct9173976 details
PRS8_HUMANPRS6A_HUMANBioGRID, HPRD, IntAct11463857 19490896 20431057 20810900 22275368 22939629 26186194 26344197 28292943 28514442 details
PRS8_HUMANSKA1_HUMANBioGRID, IntAct26496610 28514442 32296183 details
PRS8_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANRORG_HUMANBioGRID, IntAct15604093 32296183 details
PRS8_HUMANTPM1_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANPSD12_HUMANBioGRID, IntAct22863883 22939629 26344197 28292943 28514442 details
PRS8_HUMANRARA_HUMANBioGRID12503607 19144644 8598193 8603043 details
PRS8_HUMANP53_HUMANBioGRID17224908 20479273 details
PRS8_HUMANMY18B_HUMANBioGRID, HPRD16499872 details
PRS8_HUMANPSA2_HUMANBioGRID19193609 26344197 28292943 details
PRS8_HUMANTNNT1_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 details
PRS8_HUMANPSMD3_HUMANBioGRID, IntAct19490896 22863883 22939629 26344197 28292943 28514442 details
PRS8_HUMANTHA11_HUMANBioGRID, DIP, IntAct18330356 28514442 details
PRS8_HUMANTHB_HUMANBioGRID, HPRD15604093 7870181 9368056 details
PRS8_HUMANERR1_HUMANBioGRID15604093 details
PRS8_HUMANNR1I2_HUMANBioGRID, HPRD14702340 15604093 details
PRS8_HUMANRORA_HUMANBioGRID, HPRD, IntAct15604093 16189514 16713569 details
PRS8_HUMANPSMD1_HUMANBioGRID, IntAct, UniProt11361004 15831487 18922472 19490896 22275368 22863883 22939629 26344197 28292943 28514442 details
PRS8_HUMANPSD11_HUMANBioGRID, IntAct19490896 22863883 22939629 26344197 28292943 28514442 details
PRS8_HUMANBFSP2_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANUBP4_HUMANBioGRID, IntAct23022198 28514442 details
PRS8_HUMANSP1_HUMANBioGRID, HPRD10816420 18572193 details
PRS8_HUMANPSD10_HUMANBioGRID, IntAct17353931 19490896 22939629 26344197 28292943 28514442 details
PRS8_HUMANPAAF1_HUMANBioGRID, IntAct15831487 17353931 19490896 28292943 28514442 details
PRS8_HUMANTPM3_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANFOS_HUMANBioGRID, HPRD, IntAct15867431 25416956 29892012 31515488 8710853 details
PRS8_HUMANVDR_HUMANBioGRID, HPRD14702340 15604093 9831079 details
PRS8_HUMANNR1I3_HUMANBioGRID15604093 8603043 details
PRS8_HUMANLAMC1_HUMANBioGRID15604093 details
PRS8_HUMANPRS4_HUMANBioGRID, IntAct11361004 19490896 21628461 22275368 22939629 26186194 26344197 26496610 28292943 28514442 details
PRS8_HUMANAKT1_HUMANBioGRID, MINT25640309 details
PRS8_HUMANK1C40_HUMANBioGRID, IntAct25416956 29892012 31515488 details
PRS8_HUMANRORB_HUMANIntAct32296183 details
PRS8_HUMANPPARD_HUMANBioGRID15604093 details
PRS8_HUMANTFP11_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANUBE3C_HUMANBioGRID11278995 12692129 details
PRS8_HUMANNLRC4_HUMANBioGRID20085538 27974463 details
PRS8_HUMANPRS8_HUMANBioGRID17646385 28292943 details
PRS8_HUMANRD23A_HUMANBioGRID14706819 19013454 details
PRS8_HUMANMCR_HUMANBioGRID15604093 details
PRS8_HUMANRARG_HUMANBioGRID15604093 details
PRS8_HUMANK1C15_HUMANBioGRID, HPRD, IntAct16189514 29892012 31515488 details
PRS8_HUMANESR2_HUMANBioGRID, IntAct15604093 25604459 29509190 details
PRS8_HUMANTNNI2_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANERR3_HUMANBioGRID, IntAct15604093 32296183 details
PRS8_HUMANRARB_HUMANBioGRID, IntAct15604093 32296183 details
PRS8_HUMANC2TA_HUMANBioGRID18215421 20351748 26871568 details
PRS8_HUMANK1C27_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANHD_HUMANBioGRID18986984 details
PRS8_HUMANMDM2_HUMANBioGRID20479273 details
PRS8_HUMANPSA4_HUMANBioGRID22939629 26344197 28292943 details
PRS8_HUMANHARS1_HUMANBioGRID15604093 details
PRS8_HUMANHS71A_HUMANBioGRID27477512 details
PRS8_HUMANEPHA8_HUMANBioGRID, IntAct21988832 details
PRS8_HUMANBACH2_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANPRKN_HUMANBioGRID12676955 20810900 23503661 32929329 details
PRS8_HUMANRXRA_HUMANBioGRID, HPRD7870181 8598193 8603043 details
PRS8_HUMANSSNA1_HUMANBioGRID, IntAct28292943 28514442 details
PRS8_HUMANTRIPB_HUMANBioGRID8603043 details
PRS8_HUMANCC136_HUMANBioGRID32296183 details
PRS8_HUMANCF206_HUMANBioGRID, IntAct32296183 details
PRS8_HUMANNR1H3_HUMANBioGRID15604093 details
PRS8_HUMANSHPS1_HUMANBioGRID19299420 details
PRS8_HUMANHOME3_HUMANBioGRID22486777 details
PRS8_HUMANTNNI3_HUMANBioGRID15604093 details
PRS8_HUMANCDC42_HUMANBioGRID31478661 details
PRS8_HUMANPHOS_HUMANBioGRID10753654 15604093 details
PRS8_HUMANUBCP1_HUMANBioGRID27880917 28539385 details
PRS8_HUMANHNF4G_HUMANBioGRID15604093 details
PRS8_HUMANSUMO2_HUMANBioGRID32786267 details
PRS8_HUMANKCC2A_HUMANBioGRID22496558 details
PRS8_HUMANVIME_HUMANBioGRID15604093 details
PRS8_HUMANAZIN2_HUMANBioGRID30545799 details
PRS8_HUMANPKHO1_HUMANBioGRID, MINT23032291 details
PRS8_HUMANOGT1_HUMANBioGRID32994395 details
PRS8_HUMANINSI2_HUMANBioGRID19815544 details
PRS8_HUMANSCOC_HUMANBioGRID28292943 details
PRS8_HUMANLAMB1_HUMANBioGRID15604093 details
PRS8_HUMANSHOC2_HUMANBioGRID26519477 details
PRS8_HUMANHS71B_HUMANBioGRID27477512 details
PRS8_HUMANUBP14_HUMANBioGRID, IntAct17646385 19615732 26344197 30425250 31901637 details
PRS8_HUMANSEM1_HUMANBioGRID15610744 16239144 details
PRS8_HUMANPSB4_HUMANBioGRID16707496 22939629 24720748 26344197 details
PRS8_HUMANADRM1_HUMANBioGRID, IntAct, MINT, UniProt16990800 18922472 22863883 24811749 26186194 26344197 28514442 details
PRS8_HUMANPSB9_HUMANBioGRID, IntAct16957778 26186194 28514442 30833792 details
PRS8_HUMANCBP_HUMANBioGRID18662994 details
PRS8_HUMANPSB5_HUMANBioGRID21628461 22939629 26344197 details
PRS8_HUMANMYC_HUMANBioGRID12963825 29467282 details
PRS8_HUMANCSN2_HUMANBioGRID19535905 details
PRS8_HUMANPGH2_HUMANBioGRID17429597 details
PRS8_HUMANSMUF1_HUMANBioGRID, MINT23032291 details
PRS8_HUMANSEML_HUMANBioGRID15610744 16239144 details
PRS8_HUMANPSME1_HUMANBioGRID10799514 9620878 details
PRS8_HUMANTRAF6_HUMANBioGRID, IntAct14743216 17353931 28514442 details
PRS8_HUMANPSMD4_HUMANBioGRID, DIP, IntAct, MINT16990800 17646385 19589775 22939629 26344197 28514442 30479383 details
PRS8_HUMANWDR5_HUMANBioGRID19660582 details
PRS8_HUMANCDN1A_HUMANBioGRID18086887 details
PRS8_HUMANM3K5_HUMANBioGRID20843792 details
PRS8_HUMANFBX7_HUMANBioGRID27497298 27503909 details
PRS8_HUMANRD23B_HUMANBioGRID, UniProt10488153 26344197 details
PRS8_HUMANPSA1_HUMANBioGRID10799514 15831487 22939629 26344197 details
PRS8_HUMANTERA_HUMANBioGRID26337389 details
PRS8_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PRS8_HUMANNR4A1_HUMANIntAct20195357 details
PRS8_HUMANSRRM2_HUMANBioGRID16159877 details
PRS8_HUMANPSMD8_HUMANBioGRID21628461 22863883 22939629 26344197 details
PRS8_HUMANATOH1_HUMANBioGRID27542412 details
PRS8_HUMANNCOA3_HUMANBioGRID19144644 details
PRS8_HUMANFKBP8_HUMANBioGRID17573772 details
PRS8_HUMANVCAM1_HUMANBioGRID, IntAct22623428 26337389 details
PRS8_HUMANELP1_HUMANBioGRID18303054 details
PRS8_HUMANSIAH1_HUMANBioGRID20479273 details
PRS8_HUMANATX3_HUMANBioGRID17302910 30455355 details
PRS8_HUMANH31T_HUMANBioGRID18662994 details
PRS8_HUMANFXR1_HUMANMINT21653829 details
PRS8_HUMANUBP49_HUMANBioGRID23824326 details
PRS8_HUMANKIF3B_HUMANBioGRID, IntAct27173435 unassigned1312 details
PRS8_HUMANASH2L_HUMANBioGRID19660582 details
PRS8_HUMANRASM_HUMANBioGRID26519477 details
PRS8_HUMANXPC_HUMANUniProt17693435 details
PRS8_HUMANTAF10_HUMANHPRD8598193 details
PRS8_HUMANHDAC5_HUMANBioGRID21081666 details
PRS8_HUMANCBL_HUMANBioGRID20479273 details
PRS8_HUMANFGF11_HUMANBioGRID28027390 details
PRS8_HUMANHERC3_HUMANBioGRID26476452 details
PRS8_HUMANTF2B_HUMANHPRD8598193 details
PRS8_HUMANAKTIP_HUMANBioGRID27512140 details
PRS8_HUMANZFAN1_HUMANBioGRID29804830 details
PRS8_HUMANTRIM5_HUMANBioGRID22078707 details
PRS8_HUMANBAX_HUMANBioGRID20431057 details
PRS8_HUMANATX7_HUMANBioGRID11734547 details
PRS8_HUMANMDM4_HUMANBioGRID18086887 details