Entity Details

Primary name CLD10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78369
EntryNameCLD10_HUMAN
FullNameClaudin-10
TaxID9606
Evidenceevidence at protein level
Length228
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCLDN10

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0006811 ion transport
GO:0007155 cell adhesion
GO:0016021 integral component of membrane
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO:0042802 identical protein binding
GO:0043269 regulation of ion transport
GO:0070830 bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR003554 Claudin-10FamilyFamily
IPR004031 PMP-22/EMP/MP20/Claudin superfamilyFamilyFamily
IPR006187 ClaudinFamilyFamily
IPR017974 Claudin, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
617671 OMIMHELIX syndrome (HELIX)An autosomal recessive disease characterized by congenital heat intolerance, generalized anhidrosis, inability to produce tears, dry mouth, electrolyte imbalance, and ichthyosis. The disease is caused by variants affecting the gene represented in this entry.