Entity Details

Primary name PRKDC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78527
EntryNamePRKDC_HUMAN
FullNameDNA-dependent protein kinase catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length4128
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesPRKDC

GO terms

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GOName
GO:0000460 maturation of 5.8S rRNA
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0001756 somitogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0002218 activation of innate immune response
GO:0002326 B cell lineage commitment
GO:0002328 pro-B cell differentiation
GO:0002360 T cell lineage commitment
GO:0002638 negative regulation of immunoglobulin production
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004677 DNA-dependent protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007420 brain development
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 response to gamma radiation
GO:0014823 response to activity
GO:0016020 membrane
GO:0016233 telomere capping
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031648 protein destabilization
GO:0032040 small-subunit processome
GO:0032481 positive regulation of type I interferon production
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0033077 T cell differentiation in thymus
GO:0033152 immunoglobulin V(D)J recombination
GO:0033153 T cell receptor V(D)J recombination
GO:0034462 small-subunit processome assembly
GO:0034511 U3 snoRNA binding
GO:0035234 ectopic germ cell programmed cell death
GO:0042752 regulation of circadian rhythm
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045727 positive regulation of translation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048146 positive regulation of fibroblast proliferation
GO:0048511 rhythmic process
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048639 positive regulation of developmental growth
GO:0048660 regulation of smooth muscle cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0070419 nonhomologous end joining complex
GO:0097681 double-strand break repair via alternative nonhomologous end joining
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1905221 positive regulation of platelet formation
GO:2000773 negative regulation of cellular senescence
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
GO:2001229 negative regulation of response to gamma radiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR012582 NUC194DomainDomain
IPR014009 PIK-related kinaseDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR037706 DNA-dependent protein kinase catalytic subunit, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
615966 OMIMImmunodeficiency 26 with or without neurologic abnormalities (IMD26)A form of severe combined immunodeficiency characterized by reduced or absent T and B cells, recurrent candidiasis, and lower respiratory tract infections. Some patients show dysmorphic features, severe growth failure, microcephaly, seizures, and impaired neurological functions. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB05210 SF1126Drugbanksmall molecule

Interactions

173 interactions

InteractorPartnerSourcesPublicationsLink
PRKDC_HUMANTOP1_HUMANBioGRID, IntAct15848144 28415827 details
PRKDC_HUMANXRCC6_HUMANBioGRID, HPRD, I2D, IntAct10064605 10446239 10750018 11279128 15520013 17308091 19303849 20711232 21575865 21969602 22939629 26175416 26446488 26496610 28345663 30585729 33005030 8422676 9312071 details
PRKDC_HUMANNEMO_HUMANBioGRID, IntAct14743216 31932854 details
PRKDC_HUMANHXB7_HUMANBioGRID, IntAct17308091 details
PRKDC_HUMANXRCC5_HUMANBioGRID, DIP, HPRD, I2D, IntAct10207052 10446239 10750018 12393188 15520013 15758953 16857680 17308091 19303849 20023628 20085707 20711232 21679440 22404984 26344197 26446488 26496610 28154079 28345663 33005030 9312071 details
PRKDC_HUMANH2AX_HUMANBioGRID, IntAct14627815 15613478 18406329 20085707 20356835 22184063 26095369 details
PRKDC_HUMANZIC2_HUMANMINT18097573 details
PRKDC_HUMANEP300_HUMANBioGRID, MINT20808282 30110629 details
PRKDC_HUMANMKNK1_HUMANBioGRID, IntAct20936779 details
PRKDC_HUMANETS1_HUMANIntAct21575865 details
PRKDC_HUMANSPI1_HUMANIntAct21575865 details
PRKDC_HUMANPPP6_HUMANBioGRID, IntAct20065038 24255178 27684187 28330616 details
PRKDC_HUMANNR1H4_HUMANBioGRID, UniProt19833092 details
PRKDC_HUMANERG_HUMANBioGRID, IntAct21575865 24591637 details
PRKDC_HUMANDCR1C_HUMANBioGRID, HPRD, IntAct11955432 15456891 15936993 16857680 22529269 31900314 details
PRKDC_HUMANDNLI4_HUMANBioGRID, HPRD, IntAct10608806 15194694 22529269 details
PRKDC_HUMANJUN_HUMANBioGRID, HPRD, MINT25609649 8464713 details
PRKDC_HUMANXPA_HUMANBioGRID, DIP, HPRD16540648 20304803 details
PRKDC_HUMANATM_HUMANBioGRID, HPRD10464290 10608806 details
PRKDC_HUMANBRCA1_HUMANBioGRID10608806 25223785 details
PRKDC_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
PRKDC_HUMANMRE11_HUMANBioGRID10608806 details
PRKDC_HUMANETV1_HUMANIntAct21575865 details
PRKDC_HUMANP53_HUMANBioGRID, HPRD10470151 10601022 10608806 10673501 10713094 10747897 10951572 11551930 11709713 11751391 11883897 12756247 19918261 25362358 8940078 9363941 9679063 9744860 9765199 details
PRKDC_HUMANE4F1_HUMANBioGRID10608806 details
PRKDC_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
PRKDC_HUMANCHK1_HUMANBioGRID10608806 12756247 details
PRKDC_HUMANRAD17_HUMANBioGRID10608806 details
PRKDC_HUMANCTIP_HUMANBioGRID10608806 31636387 details
PRKDC_HUMANWRN_HUMANBioGRID, HPRD10608806 11889123 details
PRKDC_HUMANNCOA6_HUMANBioGRID, HPRD10823961 12519782 details
PRKDC_HUMANRFA2_HUMANBioGRID, HPRD10064605 10713094 11731442 16540648 24332808 8943020 9295339 details
PRKDC_HUMANKAT2A_HUMANBioGRID9488450 details
PRKDC_HUMANRFA1_HUMANBioGRID, HPRD10064605 21504906 24332808 details
PRKDC_HUMANPP6R2_HUMANBioGRID, IntAct20065038 28514442 details
PRKDC_HUMANC1D_HUMANBioGRID, HPRD9679063 details
PRKDC_HUMANAKT2_HUMANBioGRID15678105 16221682 details
PRKDC_HUMANABL1_HUMANBioGRID, HPRD9312071 details
PRKDC_HUMANMK08_HUMANBioGRID, HPRD11749722 details
PRKDC_HUMANAP1B1_HUMANBioGRID10608806 details
PRKDC_HUMANCIB1_HUMANBioGRID, HPRD15190070 9372844 details
PRKDC_HUMANIKKB_HUMANBioGRID9632806 details
PRKDC_HUMANHSF1_HUMANBioGRID, HPRD9325337 details
PRKDC_HUMANIKKA_HUMANBioGRID, HPRD9632806 details
PRKDC_HUMANLYN_HUMANBioGRID, HPRD9748231 details
PRKDC_HUMANPO2F1_HUMANBioGRID14612514 17213819 details
PRKDC_HUMANNCF1_HUMANBioGRID9914162 details
PRKDC_HUMANAICDA_HUMANBioGRID15634916 details
PRKDC_HUMANNCF4_HUMANBioGRID9914162 details
PRKDC_HUMANTHA_HUMANBioGRID17242407 details
PRKDC_HUMANMK09_HUMANBioGRID11749722 22366412 details
PRKDC_HUMAN1433T_HUMANBioGRID15161933 20618440 details
PRKDC_HUMANSP1_HUMANBioGRID, HPRD8422676 details
PRKDC_HUMANDHX9_HUMANBioGRID15613478 details
PRKDC_HUMANHNRPC_HUMANBioGRID14704337 details
PRKDC_HUMANTHB_HUMANBioGRID17242407 details
PRKDC_HUMANPRGR_HUMANBioGRID10750018 details
PRKDC_HUMANHDAC3_HUMANBioGRID17242407 details
PRKDC_HUMANXRCC4_HUMANBioGRID, HPRD15194694 15520013 22939629 9259561 9430729 details
PRKDC_HUMANGRAB_HUMANBioGRID, HPRD8760815 9586635 details
PRKDC_HUMANPP6R1_HUMANBioGRID20065038 details
PRKDC_HUMANCASP3_HUMANBioGRID, HPRD8642305 8804412 details
PRKDC_HUMANPRKDC_HUMANBioGRID, HPRD10750018 10823961 12186630 20065038 25223785 details
PRKDC_HUMAN4EBP1_HUMANBioGRID10713094 details
PRKDC_HUMANR144A_HUMANBioGRID24979766 28450160 30171075 details
PRKDC_HUMANH11_HUMANBioGRID20356835 details
PRKDC_HUMANNCF2_HUMANBioGRID9914162 details
PRKDC_HUMANNBN_HUMANBioGRID, HPRD15758953 details
PRKDC_HUMANPP6R3_HUMANBioGRID20065038 details
PRKDC_HUMANPDX1_HUMANBioGRID16166097 details
PRKDC_HUMANCTDP1_HUMANBioGRID21450944 details
PRKDC_HUMANH12_HUMANBioGRID18258596 details
PRKDC_HUMANMBP_HUMANBioGRID15147269 details
PRKDC_HUMANMDC1_HUMANBioGRID15377652 details
PRKDC_HUMANDCAF1_HUMANBioGRID22184063 details
PRKDC_HUMANATRIP_HUMANBioGRID, HPRD15758953 details
PRKDC_HUMANAKT1_HUMANBioGRID, HPRD15262962 15678105 details
PRKDC_HUMANROA1_HUMANBioGRID14704337 details
PRKDC_HUMANGCR_HUMANBioGRID, HPRD9038175 details
PRKDC_HUMANGSK3B_HUMANBioGRID15678105 details
PRKDC_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
PRKDC_HUMANGSK3A_HUMANBioGRID15678105 details
PRKDC_HUMANSRF_HUMANBioGRID, HPRD8407951 details
PRKDC_HUMANCHK2_HUMANBioGRID10713094 17171639 details
PRKDC_HUMANCLK1_HUMANBioGRID26167880 details
PRKDC_HUMANUBC9_HUMANBioGRID19596686 details
PRKDC_HUMANCCNB1_HUMANBioGRID26221070 details
PRKDC_HUMANFUMH_HUMANBioGRID26237645 details
PRKDC_HUMANPTEN_HUMANBioGRID31685992 details
PRKDC_HUMANRASF1_HUMANBioGRID10608806 details
PRKDC_HUMANZBT7A_HUMANBioGRID26446488 details
PRKDC_HUMANM3K3_HUMANIntAct14743216 details
PRKDC_HUMANNFKB2_HUMANIntAct14743216 details
PRKDC_HUMANIKBE_HUMANIntAct14743216 details
PRKDC_HUMAN1433B_HUMANMINT15324660 details
PRKDC_HUMANTF65_HUMANBioGRID, IntAct14743216 25331947 details
PRKDC_HUMANTNR1A_HUMANIntAct14743216 details
PRKDC_HUMANTELO2_HUMANBioGRID, IntAct, UniProt18160036 20427287 20801936 details
PRKDC_HUMAN1433G_HUMANHPRD, MINT15324660 details
PRKDC_HUMANTRADD_HUMANIntAct14743216 details
PRKDC_HUMANRELB_HUMANIntAct14743216 details
PRKDC_HUMANPARP1_HUMANBioGRID, HPRD, IntAct16794079 20085707 21575865 9398855 details
PRKDC_HUMAN1433Z_HUMANMINT15161933 20618440 details
PRKDC_HUMANRIPK3_HUMANIntAct14743216 details
PRKDC_HUMANESR1_HUMANBioGRID, IntAct16794079 21182205 details
PRKDC_HUMANTNR1B_HUMANIntAct14743216 details
PRKDC_HUMANILF2_HUMANBioGRID, HPRD, MINT17389650 20808282 9442054 details
PRKDC_HUMANCSK22_HUMANI2D20711232 details
PRKDC_HUMANCDC5L_HUMANBioGRID, MINT11101529 20467437 details
PRKDC_HUMANTYY1_HUMANBioGRID, UniProt18026119 details
PRKDC_HUMANAIRE_HUMANBioGRID, IntAct20085707 details
PRKDC_HUMANLRRK2_HUMANBioGRID, IntAct17400507 19826009 31046837 details
PRKDC_HUMANTTI1_HUMANBioGRID, UniProt20371770 20427287 20810650 details
PRKDC_HUMANIBP3_HUMANIntAct23178489 details
PRKDC_HUMANEGFR_HUMANBioGRID, IntAct23178489 23956138 details
PRKDC_HUMANANDR_HUMANBioGRID, IntAct15640154 26175416 details
PRKDC_HUMANKPCD_HUMANHPRD, IntAct16611985 9774685 details
PRKDC_HUMANH31_HUMANBioGRID, DIP, IntAct20080577 20504901 22404984 26527279 29568061 details
PRKDC_HUMANRARA_HUMANIntAct25303530 details
PRKDC_HUMANSIN1_HUMANMolecular Connections24365180 details
PRKDC_HUMANCHD1L_HUMANBioGRID, DIP19661379 19666485 details
PRKDC_HUMANISG15_HUMANBioGRID, IntAct26259872 33024031 details
PRKDC_HUMANILF3_HUMANBioGRID21969602 9442054 details
PRKDC_HUMANDEAF1_HUMANUniProt22442688 details
PRKDC_HUMANIF2B_HUMANBioGRID, HPRD9442054 details
PRKDC_HUMANRECQ5_HUMANBioGRID19270065 details
PRKDC_HUMANPCNA_HUMANBioGRID, HPRD12171929 details
PRKDC_HUMANSIR6_HUMANBioGRID20157594 24169447 details
PRKDC_HUMANPMS2_HUMANBioGRID17148452 details
PRKDC_HUMANSMRCD_HUMANBioGRID21549307 details
PRKDC_HUMANVIGLN_HUMANBioGRID15723802 details
PRKDC_HUMANMGMT_HUMANBioGRID16226712 details
PRKDC_HUMANTERF1_HUMANBioGRID18160036 details
PRKDC_HUMANMLH1_HUMANBioGRID17148452 details
PRKDC_HUMANMS3L1_HUMANBioGRID20479123 details
PRKDC_HUMANCSK21_HUMANBioGRID22404984 details
PRKDC_HUMANKAT8_HUMANBioGRID20479123 details
PRKDC_HUMANBIRC5_HUMANBioGRID20394854 details
PRKDC_HUMANITA4_HUMANBioGRID22623428 details
PRKDC_HUMANBMI1_HUMANBioGRID20668194 details
PRKDC_HUMANCAF1A_HUMANBioGRID21209461 details
PRKDC_HUMANZN840_HUMANIntAct30021884 details
PRKDC_HUMANANC2_HUMANBioGRID26221070 details
PRKDC_HUMANPP2AA_HUMANBioGRID20065038 details
PRKDC_HUMANH33_HUMANBioGRID20504901 details
PRKDC_HUMANLOX15_HUMANBioGRID18785202 details
PRKDC_HUMANARHG6_HUMANBioGRID19918261 details
PRKDC_HUMANMSH6_HUMANBioGRID21075794 details
PRKDC_HUMANKAT5_HUMANBioGRID16603769 details
PRKDC_HUMANATOH1_HUMANBioGRID27542412 details
PRKDC_HUMANPNKP_HUMANBioGRID15385968 details
PRKDC_HUMANAHSA1_HUMANBioGRID22504172 details
PRKDC_HUMANHDAC5_HUMANBioGRID21081666 details
PRKDC_HUMANHIF1A_HUMANBioGRID15272235 27320910 details
PRKDC_HUMANHS90A_HUMANBioGRID, HPRD16263121 2507541 details
PRKDC_HUMANXRCC1_HUMANBioGRID18678286 details
PRKDC_HUMANUBXN6_HUMANBioGRID22337587 details
PRKDC_HUMANCDK9_HUMANBioGRID26209609 27684187 details
PRKDC_HUMANAKTIP_HUMANBioGRID27535835 details
PRKDC_HUMANELP1_HUMANBioGRID18303054 details
PRKDC_HUMANNKX21_HUMANBioGRID28192407 details
PRKDC_HUMANARAF_HUMANBioGRID29777862 details
PRKDC_HUMANTRI29_HUMANBioGRID26095369 details
PRKDC_HUMANRUVB2_HUMANBioGRID25875766 details
PRKDC_HUMANUBR5_HUMANBioGRID31365120 32867711 details
PRKDC_HUMANHMGB2_HUMANHPRD9722660 details
PRKDC_HUMANFZR1_HUMANBioGRID26221070 details
PRKDC_HUMANSFPQ_HUMANBioGRID30725116 details
PRKDC_HUMANHMGB1_HUMANHPRD9722660 details
PRKDC_HUMANFLNA_HUMANBioGRID20305393 details
PRKDC_HUMANANR55_HUMANBioGRID31620119 details
PRKDC_HUMANSGO1_HUMANHPRD16541024 details
PRKDC_HUMANHXC4_HUMANHPRD11279128 details