Entity Details

Primary name ADA17_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78536
EntryNameADA17_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 17
TaxID9606
Evidenceevidence at protein level
Length824
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesADAM17

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002446 neutrophil mediated immunity
GO:0002467 germinal center formation
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005112 Notch binding
GO:0005138 interleukin-6 receptor binding
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010820 positive regulation of T cell chemotaxis
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016485 protein processing
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
GO:0030183 B cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032496 response to lipopolysaccharide
GO:0032722 positive regulation of chemokine production
GO:0033025 regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033627 cell adhesion mediated by integrin
GO:0035313 wound healing, spreading of epidermal cells
GO:0035624 receptor transactivation
GO:0042493 response to drug
GO:0042987 amyloid precursor protein catabolic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045121 membrane raft
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0046872 metal ion binding
GO:0048536 spleen development
GO:0048870 cell motility
GO:0050830 defense response to Gram-positive bacterium
GO:0051272 positive regulation of cellular component movement
GO:0071403 cellular response to high density lipoprotein particle stimulus
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1905564 positive regulation of vascular endothelial cell proliferation

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR032029 ADAM17, membrane-proximal domainDomainDomain
IPR034025 ADAM10/ADAM17 catalytic domainDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614328 OMIMInflammatory skin and bowel disease, neonatal, 1 (NISBD1)A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB06943 (3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiolDrugbanksmall molecule
DB07079 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiolDrugbanksmall molecule
DB07121 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDEDrugbanksmall molecule
DB07145 (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDEDrugbanksmall molecule
DB07147 methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylateDrugbanksmall molecule
DB07189 (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acidDrugbanksmall molecule
DB07233 N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophanDrugbanksmall molecule
DB07964 (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDEDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
ADA17_HUMANMD2L1_HUMANBioGRID, HPRD, UniProt10527948 11741929 details
ADA17_HUMANPTN3_HUMANHPRD, MINT12207026 details
ADA17_HUMANDLG1_HUMANBioGRID, HPRD, MINT12668732 18930083 details
ADA17_HUMANPDIA3_HUMANBioGRID, MINT17170699 details
ADA17_HUMANA4_HUMANIntAct9774383 details
ADA17_HUMANJAG1_HUMANIntAct23375636 details
ADA17_HUMANITB1_HUMANIntAct, UniProt22413019 30455686 details
ADA17_HUMANPDPK1_HUMANDIP16641105 details
ADA17_HUMANMK01_HUMANBioGRID12058067 details
ADA17_HUMANTIMP3_HUMANBioGRID, HPRD12044879 details
ADA17_HUMANTNR1A_HUMANBioGRID17010968 details
ADA17_HUMANTNR1B_HUMANBioGRID17010968 details
ADA17_HUMANFHL2_HUMANHPRD16619241 details
ADA17_HUMANTGFA_HUMANBioGRID, HPRD, IntAct11823465 18930083 25241761 details
ADA17_HUMANSRC_HUMANDIP16641105 details
ADA17_HUMANITAV_HUMANUniProt30455686 details
ADA17_HUMANSNX18_HUMANUniProt25036101 details
ADA17_HUMANSNX9_HUMANUniProt25036101 details
ADA17_HUMANSNX33_HUMANUniProt25036101 details
ADA17_HUMANPACN1_HUMANUniProt25036101 details
ADA17_HUMANPACN2_HUMANUniProt25036101 details
ADA17_HUMANPACN3_HUMANUniProt25036101 details
ADA17_HUMANEED_HUMANBioGRID23317503 details
ADA17_HUMANPAXI_HUMANBioGRID23317503 details
ADA17_HUMANNOTC1_HUMANHPRD10882063 9620803 details
ADA17_HUMANTNFA_HUMANHPRD10799478 12135369 details
ADA17_HUMANERBB4_HUMANHPRD15534001 details
ADA17_HUMANMD2L2_HUMANHPRD10527948 details
ADA17_HUMANSH319_HUMANHPRD15280379 details
ADA17_HUMANTNF11_HUMANHPRD10224132 details