Entity Details

Primary name	NFKB2_HUMAN
Entity type	UniProt
Source	Source Link

Details

Accession	Q00653
EntryName	NFKB2_HUMAN
FullName	Nuclear factor NF-kappa-B p100 subunit
TaxID	9606
Evidence	evidence at protein level
Length	900
SequenceStatus	complete
DateCreated	1993-10-01
DateModified	2021-06-02

Ontological Relatives

Genes

NFKB2

GO terms

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GO	Name
GO:0000785	chromatin
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002268	follicular dendritic cell differentiation
GO:0002467	germinal center formation
GO:0003700	DNA-binding transcription factor activity
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription by RNA polymerase II
GO:0007568	aging
GO:0030198	extracellular matrix organization
GO:0032481	positive regulation of type I interferon production
GO:0032496	response to lipopolysaccharide
GO:0033257	Bcl3/NF-kappaB2 complex
GO:0034097	response to cytokine
GO:0038061	NIK/NF-kappaB signaling
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0048511	rhythmic process
GO:0048536	spleen development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1990837	sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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Domain	Name	Category	Type
IPR000451	NF-kappa-B/Dorsal	Family	Family
IPR000488	Death domain	Domain	Domain
IPR002110	Ankyrin repeat	Repeat	Repeat
IPR002909	IPT domain	Domain	Domain
IPR008967	p53-like transcription factor, DNA-binding	Family	Homologous superfamily
IPR011029	Death-like domain superfamily	Family	Homologous superfamily
IPR011539	Rel homology domain (RHD), DNA-binding domain	Domain	Domain
IPR013783	Immunoglobulin-like fold	Family	Homologous superfamily
IPR014756	Immunoglobulin E-set	Family	Homologous superfamily
IPR020683	Ankyrin repeat-containing domain	Domain	Domain
IPR030492	Rel homology domain, conserved site	Site	Conserved site
IPR030497	Nuclear factor NF-kappa-B, p100 subunit	Family	Family
IPR032397	Rel homology dimerisation domain	Domain	Domain
IPR033926	NFkappaB IPT domain	Domain	Domain
IPR036770	Ankyrin repeat-containing domain superfamily	Family	Homologous superfamily
IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily	Family	Homologous superfamily

Diseases

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Disease ID	Source	Name	Description
615577	OMIM	Immunodeficiency, common variable, 10 (CVID10)	A primary immunodeficiency characterized by childhood-onset of recurrent infections, hypogammaglobulinemia, and decreased numbers of memory and marginal zone B-cells. Some patients may develop autoimmune features and have circulating autoantibodies. An unusual feature is central adrenal insufficiency. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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Drug	Name	Source	Type
DB00843	Donepezil	Drugbank	small molecule
DB01296	Glucosamine	Drugbank	small molecule
DB05212	HE3286	Drugbank	small molecule
DB05451	P54	Drugbank	small molecule
DB05464	NOX-700	Drugbank	small molecule
DB05471	SGN-30	Drugbank	biotech
DB05487	Custirsen	Drugbank	small molecule
DB05559	NF-kappaB Decoy	Drugbank	small molecule
DB05767	Andrographolide	Drugbank	small molecule
DB13751	Glycyrrhizic acid	Drugbank	small molecule
DB13961	Fish oil	Drugbank	biotech
DB14059	SC-236	Drugbank	small molecule

Interactions

109 interactions

Interactor	Partner	Sources	Publications	Link
NFKB2_HUMAN	IKBE_HUMAN	BioGRID, HPRD, IntAct	14743216 9315679	details
NFKB2_HUMAN	TF65_HUMAN	BioGRID, HPRD, IntAct	14743216 16009713 16940413 17962807 27609421 29084252 8413211	details
NFKB2_HUMAN	IKKA_HUMAN	BioGRID, HPRD, IntAct	14743216 15140882 16303288 16651533 17563756 18617892	details
NFKB2_HUMAN	NFKB1_HUMAN	BioGRID, HPRD, IntAct, MINT	14743216 15169888 15660126 21988832 25609649 27609421	details
NFKB2_HUMAN	FBW1A_HUMAN	BioGRID, HPRD, MINT	11994270 14676825 15140882 16303288 18617892 22388891 25900982	details
NFKB2_HUMAN	EPS8_HUMAN	BioGRID, IntAct	21988832	details
NFKB2_HUMAN	BCL3_HUMAN	BioGRID, HPRD, IntAct	11707390 14678988 17962807 20558726 20800578 28689659 30833792 8453667	details
NFKB2_HUMAN	IKBZ_HUMAN	BioGRID, IntAct	20211142	details
NFKB2_HUMAN	MEN1_HUMAN	BioGRID, HPRD	11526476	details
NFKB2_HUMAN	SP1_HUMAN	BioGRID	7933095	details
NFKB2_HUMAN	GCR_HUMAN	BioGRID, HPRD	7823959	details
NFKB2_HUMAN	NKRF_HUMAN	BioGRID, HPRD	10562553	details
NFKB2_HUMAN	T22D3_HUMAN	BioGRID, HPRD	11468175	details
NFKB2_HUMAN	PSD11_HUMAN	BioGRID, HPRD	12185077	details
NFKB2_HUMAN	REQU_HUMAN	BioGRID	20460684	details
NFKB2_HUMAN	FBW1B_HUMAN	BioGRID	22017875 25332235 25515538 25900982 28004927	details
NFKB2_HUMAN	REL_HUMAN	BioGRID, HPRD, IntAct	14743216 17962807 26186194 27609421 28514442 8152812 8413211	details
NFKB2_HUMAN	IKBA_HUMAN	BioGRID, HPRD, IntAct	14743216 26186194 26496610 28514442	details
NFKB2_HUMAN	IKBB_HUMAN	BioGRID, HPRD, IntAct	14743216 26186194 28514442	details
NFKB2_HUMAN	AIFM1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HS71L_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	BIP_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	U5S1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HSP7C_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SYRC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	MBB1A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	ILF2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	GRP75_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PRP8_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SYMC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS5_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS10_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RLA2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	IQGA1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS3_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RPOM_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	DNJA1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SYIC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS18_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SYEP_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PABP1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	EF1A2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	DDX21_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	MATR3_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RT29_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PYR1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	ECHB_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TIM50_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	CLH1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	IKKB_HUMAN	HPRD, IntAct	14743216	details
NFKB2_HUMAN	RS11_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS14_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	FAS_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	GEMI4_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL7_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	ECHA_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBB6_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	CALM2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBB5_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	DHX9_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TF3C1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBB4A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	NFKB2_HUMAN	BioGRID, HPRD, IntAct	14743216 17962807 22388891	details
NFKB2_HUMAN	CCAR2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RLA0L_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	DNJA3_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HNRPU_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL18_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS19_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	UBB_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS8_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HNRPC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SFPQ_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PARP1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS4X_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HS90A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	NUCL_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PRKDC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBA3C_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBA3D_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL7A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL11_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS3A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL13_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HNRPM_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS24_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	H2B1B_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	XRCC5_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	USP9X_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS15A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS16_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS27_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBA1A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RELB_HUMAN	BioGRID, HPRD, IntAct	12505990 14678988 14743216 17962807 22388891 22864569 27609421 28514442	details
NFKB2_HUMAN	GTF2I_HUMAN	HPRD, IntAct	14743216	details
NFKB2_HUMAN	SUMO1_HUMAN	MINT	18617892	details
NFKB2_HUMAN	UBC_HUMAN	MINT	18617892	details
NFKB2_HUMAN	M3K14_HUMAN	BioGRID, HPRD, IntAct	11239468 17563756 30833792 31980649	details
NFKB2_HUMAN	FBXW7_HUMAN	BioGRID	14743216 22388891 22864569 25720964 32350066	details
NFKB2_HUMAN	TS101_HUMAN	BioGRID	19542561	details
NFKB2_HUMAN	TNAP3_HUMAN	BioGRID	24008839	details
NFKB2_HUMAN	STAT3_HUMAN	BioGRID	16651533 25771405	details
NFKB2_HUMAN	VDR_HUMAN	BioGRID	26269414	details
NFKB2_HUMAN	ZHX2_HUMAN	BioGRID	30026228	details
NFKB2_HUMAN	IASPP_HUMAN	BioGRID	29743530	details
NFKB2_HUMAN	STF1_HUMAN	HPRD	12917325	details
NFKB2_HUMAN	HDAC4_HUMAN	HPRD	12917325	details
NFKB2_HUMAN	HDAC5_HUMAN	HPRD	12917325	details
NFKB2_HUMAN	SIN3A_HUMAN	HPRD	17962807	details