Entity Details

Primary name AT2B2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01814
EntryNameAT2B2_HUMAN
FullNamePlasma membrane calcium-transporting ATPase 2
TaxID9606
Evidenceevidence at protein level
Length1243
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesATP2B2

GO terms

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GOName
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007605 sensory perception of sound
GO:0008022 protein C-terminus binding
GO:0019829 ATPase-coupled cation transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0030182 neuron differentiation
GO:0034220 ion transmembrane transport
GO:0043231 intracellular membrane-bounded organelle
GO:0046872 metal ion binding
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0070062 extracellular exosome
GO:0098793 presynapse
GO:0098839 postsynaptic density membrane
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:1903779 regulation of cardiac conduction
GO:1905056 P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905059 P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR006408 P-type ATPase, subfamily IIBFamilyFamily
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminalDomainDomain
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR030322 Plasma membrane calcium-transporting ATPase 2FamilyFamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01159 HalothaneDrugbanksmall molecule
DB01189 DesfluraneDrugbanksmall molecule