Entity Details

Primary name KPCE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02156
EntryNameKPCE_HUMAN
FullNameProtein kinase C epsilon type
TaxID9606
Evidenceevidence at protein level
Length737
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCE

GO terms

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GOName
GO:0002281 macrophage activation involved in immune response
GO:0003785 actin monomer binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0004699 calcium-independent protein kinase C activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0008047 enzyme activator activity
GO:0010634 positive regulation of epithelial cell migration
GO:0010763 positive regulation of fibroblast migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0018105 peptidyl-serine phosphorylation
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0030546 signaling receptor activator activity
GO:0030838 positive regulation of actin filament polymerization
GO:0031397 negative regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032467 positive regulation of cytokinesis
GO:0035276 ethanol binding
GO:0035556 intracellular signal transduction
GO:0035641 locomotory exploration behavior
GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0043278 response to morphine
GO:0043410 positive regulation of MAPK cascade
GO:0045111 intermediate filament cytoskeleton
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050996 positive regulation of lipid catabolic process
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051301 cell division
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070257 positive regulation of mucus secretion
GO:0071361 cellular response to ethanol
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071456 cellular response to hypoxia
GO:0071889 14-3-3 protein binding
GO:0071944 cell periphery
GO:0090303 positive regulation of wound healing
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:2000650 negative regulation of sodium ion transmembrane transporter activity
GO:2001031 positive regulation of cellular glucuronidation

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014376 Protein kinase C, delta/epsilon/eta/theta typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR027274 Protein kinase C, epsilonFamilyFamily
IPR034669 Novel protein kinase C epsilon, catalytic domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB06064 KAI-1455Drugbanksmall molecule
DB11752 Bryostatin 1Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

81 interactions

InteractorPartnerSourcesPublicationsLink
KPCE_HUMANPECA1_HUMANHPRD, IntAct10801826 details
KPCE_HUMAN1433Z_HUMANBioGRID, IntAct, MINT11950841 19662078 31980649 details
KPCE_HUMANM4K4_HUMANBioGRID, IntAct20936779 details
KPCE_HUMANDESP_HUMANBioGRID, IntAct20936779 details
KPCE_HUMANUD17_HUMANbhf-ucl18556656 details
KPCE_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
KPCE_HUMANTCAM2_HUMANDIP16757566 details
KPCE_HUMANKPCE_HUMANBioGRID, DIP, HPRD10945988 11062054 12640464 16757566 31980649 details
KPCE_HUMANKPCD1_HUMANDIP, HPRD10092595 19011111 details
KPCE_HUMANA4_HUMANIntAct32814053 details
KPCE_HUMANSYUA_HUMANHPRD, IntAct10407019 32814053 details
KPCE_HUMANGRP3_HUMANBioGRID15213298 details
KPCE_HUMANDCE2_HUMANBioGRID, HPRD15147202 details
KPCE_HUMANDCE1_HUMANBioGRID, HPRD15147202 details
KPCE_HUMANADAP1_HUMANBioGRID, HPRD12893243 details
KPCE_HUMANVDAC1_HUMANBioGRID, HPRD12663490 details
KPCE_HUMANRACK1_HUMANBioGRID, HPRD11709417 11956211 details
KPCE_HUMANGNA12_HUMANBioGRID8824244 details
KPCE_HUMANGNA13_HUMANBioGRID, HPRD8824244 details
KPCE_HUMANTIAM1_HUMANBioGRID, HPRD10212259 details
KPCE_HUMANPDLI5_HUMANBioGRID, HPRD8940095 details
KPCE_HUMANAFAP1_HUMANBioGRID, HPRD12134071 details
KPCE_HUMANKAT5_HUMANBioGRID17851107 details
KPCE_HUMANH11_HUMANBioGRID16314418 details
KPCE_HUMANMARK2_HUMANBioGRID19011111 details
KPCE_HUMANPP14A_HUMANBioGRID, HPRD15003508 details
KPCE_HUMANIKKB_HUMANBioGRID23123196 details
KPCE_HUMANITB2_HUMANBioGRID11700305 details
KPCE_HUMANATF2_HUMANBioGRID22304920 details
KPCE_HUMANELAV1_HUMANBioGRID17392515 details
KPCE_HUMANNUMB_HUMANBioGRID, HPRD17203073 details
KPCE_HUMANNANOG_HUMANBioGRID23708658 details
KPCE_HUMANRAD9A_HUMANBioGRID12628935 details
KPCE_HUMANTAU_HUMANBioGRID11104762 details
KPCE_HUMANBRAF_HUMANBioGRID, HPRD, MINT16810323 21625473 details
KPCE_HUMANKPCA_HUMANBioGRID, IntAct, MINT16810323 31980649 details
KPCE_HUMANKS6A2_HUMANMINT16810323 details
KPCE_HUMANBAX_HUMANIntAct17668322 details
KPCE_HUMANHS90B_HUMANBioGRID, IntAct20353823 22939624 31980649 details
KPCE_HUMANSTAT1_HUMANBioGRID, IntAct20353823 24825907 details
KPCE_HUMANPR15A_HUMANIntAct29109149 details
KPCE_HUMANKS6B2_HUMANBioGRID, HPRD, MINT16810323 21625473 details
KPCE_HUMANSIN1_HUMANIntAct28934384 details
KPCE_HUMANPDPK1_HUMANHPRD, IntAct10945988 11062054 12640464 28934384 details
KPCE_HUMANHS90A_HUMANBioGRID, IntAct20558438 22939624 31980649 details
KPCE_HUMANADT1_HUMANBioGRID, HPRD12663490 details
KPCE_HUMANHXK2_HUMANBioGRID, HPRD12663490 details
KPCE_HUMANMK01_HUMANBioGRID, HPRD11350735 details
KPCE_HUMANRAF1_HUMANBioGRID, HPRD11350735 details
KPCE_HUMANCXA1_HUMANBioGRID, HPRD10679481 details
KPCE_HUMANCFTR_HUMANBioGRID, HPRD11956211 details
KPCE_HUMANMYH9_HUMANBioGRID11897493 details
KPCE_HUMANCOPB2_HUMANBioGRID, HPRD11897493 9360998 details
KPCE_HUMANK2C1_HUMANBioGRID, HPRD11897493 details
KPCE_HUMANACTS_HUMANBioGRID, HPRD11897493 8567732 details
KPCE_HUMANPK3CB_HUMANBioGRID, HPRD9822674 details
KPCE_HUMANK2C8_HUMANBioGRID1374067 details
KPCE_HUMANK1C18_HUMANBioGRID, HPRD1374067 15368451 7523419 details
KPCE_HUMANIBTK_HUMANBioGRID21482705 details
KPCE_HUMANNEMO_HUMANBioGRID23123196 details
KPCE_HUMANIL32_HUMANBioGRID25178676 25245533 details
KPCE_HUMANZBT16_HUMANBioGRID25178676 details
KPCE_HUMANBAD_HUMANBioGRID20179209 details
KPCE_HUMANBCL6_HUMANBioGRID25245533 details
KPCE_HUMANTOM20_HUMANBioGRID20558438 details
KPCE_HUMANPLCG1_HUMANBioGRID17561374 details
KPCE_HUMANOPRD_HUMANHPRD11085981 details
KPCE_HUMANSRC_HUMANHPRD11834516 details
KPCE_HUMANCNN1_HUMANHPRD9312127 details
KPCE_HUMANCOPB_HUMANHPRD11897493 details
KPCE_HUMANTRPV1_HUMANHPRD11884385 14523239 details
KPCE_HUMANNMDE4_HUMANHPRD10862698 details
KPCE_HUMANNMDZ1_HUMANHPRD10862698 details
KPCE_HUMANBTK_HUMANHPRD11788586 7522330 details
KPCE_HUMANGRM5_HUMANHPRD15894802 details
KPCE_HUMANACTC_HUMANHPRD11968018 details
KPCE_HUMANCLAT_HUMANHPRD15381704 details
KPCE_HUMANMK03_HUMANHPRD16461926 16810323 details
KPCE_HUMANFYN_HUMANHPRD8621384 details
KPCE_HUMANMYH2_HUMANHPRD11897493 details
KPCE_HUMANB3A3_HUMANHPRD11739292 details